학술논문
Inflammatory Response and Activation of Coagulation after COVID-19 Infection
Document Type
Report
Author
Teodoro, Anna Glória Fonseca; Rodrigues, Wellington Francisco; Farnesi-de-Assunção, Thais Soares; Borges, Anna V. Bernardes e; Obata, Malu Mateus Santos; Neto, José Rodrigues do Carmo; da Silva, Djalma A. Alves; Andrade-Silva, Leonardo E.; Desidério, Chamberttan S.; Costa-Madeira, Juliana C.; Barbosa, Rafaela M.; Cunha, Andrezza C. C. Hortolani; Pereira, Loren Q.; de Vito, Fernanda Bernadelli; Vaz Tanaka, Sarah Cristina Sato; Helmo, Fernanda R.; Lemes, Marcela Rezende; Barbosa, Laís M.; Trevisan, Rafael O.; Mundim, Fabiano V.; Oliveira-Scussel, Ana Carolina M.; Junior, Paulo Roberto Resende; Monteiro, Ivan B.; Ferreira, Yulsef M.; Machado, Guilherme H.; Ferreira-Paim, Kennio; Moraes-Souza, Hélio; de Oliveira, Carlo José Freire; Rodrigues Júnior, Virmondes; Silva, Marcos Vinicius da
Source
Viruses. April, 2023, Vol. 15 Issue 4
Subject
Language
English
ISSN
1999-4915
Abstract
SARS-CoV-2 (COVID-19) infection is responsible for causing a disease with a wide spectrum of clinical presentations. Predisposition to thromboembolic disease due to excessive inflammation is also attributed to the disease. The objective of this study was to characterize the clinical and laboratory aspects of hospitalized patients, in addition to studying the pattern of serum cytokines, and associate them with the occurrence of thromboembolic events. Methodology: A retrospective cohort study with 97 COVID-19 patients hospitalized from April to August 2020 in the Triângulo Mineiro macro-region was carried out. A review of medical records was conducted to evaluate the clinical and laboratory aspects and the frequency of thrombosis, as well as the measurement of cytokines, in the groups that presented or did not present a thrombotic event. Results: There were seven confirmed cases of thrombotic occurrence in the cohort. A reduction in the time of prothrombin activity was observed in the group with thrombosis. Further, 27.8% of all patients had thrombocytopenia. In the group that had thrombotic events, the levels of IL1b, IL-10, and IL2 were higher (p < 0.05). Conclusions: In the studied sample, there was an increase in the inflammatory response in patients with thrombotic events, confirmed by the increase in cytokines. Furthermore, in this cohort, a link was observed between the IL-10 percentage and an increased chance of a thrombotic event.
Author(s): Anna Glória Fonseca Teodoro [1,†]; Wellington Francisco Rodrigues (corresponding author) [1,*,†]; Thais Soares Farnesi-de-Assunção [1]; Anna V. Bernardes e Borges [1]; Malu Mateus Santos Obata [1]; José Rodrigues do [...]
Author(s): Anna Glória Fonseca Teodoro [1,†]; Wellington Francisco Rodrigues (corresponding author) [1,*,†]; Thais Soares Farnesi-de-Assunção [1]; Anna V. Bernardes e Borges [1]; Malu Mateus Santos Obata [1]; José Rodrigues do [...]