학술논문
Removal of cardiac AL amyloid with positive remodelling of cardiomyocytes and of restrictive cardiomyopathy
Document Type
Report
Author
Source
ESC Heart Failure. December 2022, Vol. 9 Issue 6, p4330, 5 p.
Subject
Language
English
Abstract
Introduction Cardiac amyloid (CA) is an infiltrative myocardial disease caused by interstitial deposition of beta fibrils,[sup.1,2] giving rise to a cardiomyopathy with restrictive phenotype. The generation of amyloidogenic proteins can [...]
: Herein, we describe histological mobilization of light chain cardiac amyloid documented by sequential left ventricular endomyocardial biopsies. These findings were associated with positive remodelling of cardiomyocytes and of restrictive cardiomyopathy resulting from 14 courses of chemotherapy over 17 years of time. Histological and ultrastructural findings of light chain cardiac amyloid removal led to increase in cardiomyocyte dimension and electrocardiogram voltages, reduction of biventricular wall thickness with improvement of left ventricular diastolic function, and NYHA class shifting from III to I.
: Herein, we describe histological mobilization of light chain cardiac amyloid documented by sequential left ventricular endomyocardial biopsies. These findings were associated with positive remodelling of cardiomyocytes and of restrictive cardiomyopathy resulting from 14 courses of chemotherapy over 17 years of time. Histological and ultrastructural findings of light chain cardiac amyloid removal led to increase in cardiomyocyte dimension and electrocardiogram voltages, reduction of biventricular wall thickness with improvement of left ventricular diastolic function, and NYHA class shifting from III to I.