부산대학교 도서관

PURPOSE To elucidate which swept-source optical coherence tomography (OCT)--derived optic nerve head (ONH) parameters are associated with longer axial length (AXL) in healthy myopic eyes. DESIGN Prospective cross-sectional observational study. METHODS Two hundred eleven healthy eyes of 140 participants (96 emmetropic-mild myopic [AXL: 22.2-24.5 mm], 83 moderately myopic [24.5-26.0 mm], and 32 highly myopic [26.0-27.4 mm] eyes) were enrolled. Bruch membrane opening (BMO), anterior scleral canal opening (ASCO) area and ovality, minimum rim width, parameters defining misalignment between the BMO and ASCO planes, OCT-defined region of perineural canal retinal epithelium atrophy and externally oblique choroidal border tissue, circumpapillary retinal nerve fiber layer thickness (cpRNFLT), circumpapillary choroidal thickness (cpChT), lamina cribrosa parameters, and peripapillary scleral (PPS) angle were calculated from BMO-centered radial scans reconstructed from 3D raster scans. Multivariate linear mixed models were used to elucidate ONH parameters that are independently associated with AXL. RESULTS Longer AXL was associated with a greater misalignment between ASCO and BMO planes, larger region of externally oblique choroidal border tissue, thinner cpChT, larger PPS angle, larger ASCO area, and thicker cpRNFLT (all P < .040 after Bonferroni's correction for number of included explanatory variables). CONCLUSIONS A greater misalignment between BMO and ASCO planes, thinner choroid, a more posteriorly bowed PPS, an enlargement of ASCO, and thicker cpRNFLT were each associated with longer AXL. An enhanced understanding of these AXL-associated configurations should provide essential information to improve our ability to detect glaucoma-induced ONH morphology in myopic eyes. Author Affiliation: (a) From the Department of Ophthalmology, Graduate School of Medicine, University of Tokyo (H.S., M.K., M.Ai.), Tokyo, Japan (b) Kanto Central Hospital of the Mutual Aid Association of Public School Teachers (M.Ar.), Tokyo, Japan (c) Center Hospital of the National Center for Global Health and Medicine (H.M.), Tokyo, Japan (d) Japan Community Health care Organization Tokyo Shinjuku Medical Center (N.E.), Tokyo, Japan (e) R&D Division, Topcon Corporation (T.K.), Tokyo, Japan (f) Department of Ophthalmology, Kanazawa University Graduate School of Medical Sciences (K.S., T.H.), Kanazawa, Japan (g) Department of Innovative Visual Science, Osaka University Graduate School of Medicine (A.M.), Osaka, Japan (h) Department of Myopia Control Research, Aichi Medical University Medical School (A.M.), Nagakute, Japan (i) Tajimi Iwase Eye Clinic (A.I.), Tajimi, Japan (j) Department of Ophthalmology, Toho University Ohashi Medical Center (G.T.), Tokyo, Japan (k) Department of Ophthalmology, Graduate School of Medicine, Tohoku University (T.N.), Sendai, Japan (l) Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University (K.O.-M.), Tokyo, Japan (m) Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital (T.-W.K.), Seongnam, Korea (n) Department of Ophthalmology, LKS Faculty of Medicine, University of Hong Kong (C.K.S.L.), Hong Kong Special Administrative Region, China (o) Hamilton Glaucoma Center, Shiley Eye Institute (L.M.Z., R.N.W.), and the Viterbi Family Department of Ophthalmology (L.M.Z., R.N.W.), University of California San Diego, La Jolla, California, USA. * Inquiries to Hitomi Saito, Department of Ophthalmology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan Article History: Received 31 August 2022; Revised 1 December 2022; Accepted 6 January 2023 Byline: Hitomi Saito [hitomi8678@gmail.com] (a,*), Mitsuki Kambayashi (a), Makoto Araie (b), Hiroshi Murata (c), Nobuko Enomoto (d), Tsutomu Kikawa (e), Kazuhisa Sugiyama (f), Tomomi Higashide (f), Atsuya Miki (g,h), Aiko Iwase (i), Goji Tomita (j), Toru Nakazawa (k), Makoto Aihara (a), Kyoko Ohno-Matsui (l), Tae-Woo Kim (m), Christopher Kai Shun Leung (n), Linda M. Zangwill (o), Robert N. Weinreb (o)