부산대학교 도서관

Introduction Benign essential blepharospasm is a focal dystonia characterized by involuntary eyelid closure. It is relatively rare disease which occurs between the fifth and seventh decade of life, and the [...]
The aim of this study was to determine the effect of botulinum toxin type A and satisfaction in patients with essential blepharospasm. The study included 12 subjects suffering from essential blepharospasm who received therapy with botulinum toxin type A injections. Respondents were given a Blepharospasm Disability Index (BSDI) survey before and three weeks after the procedure with questions related to quality of life. They were also given a Jankovic Rating Scale with questions related to the severity and frequency of symptoms. The overall level of difficulties was reduced, meaning the quality of life increased after the application of botulinum toxin, and the study found that the increase was statistically significant (p = 0.003). The severity of symptoms after the application of botulinum toxin was reduced, which meant that there was a decrease in the severity of the difficulties, and the study found a statistically significant difference (p=0.003). The frequency of symptoms was reduced after botulinum toxin administration, and the study revealed a statistically significant difference (p = 0.012). From the results of this study, we can determine that the use of botulinum toxin type A increases the quality of life and that the severity and frequency of symptoms are statistically significantly reduced. Key words: notulinum toxin type A; essential blepharospasm; dystonia; Blepharospasm Disability Index; Jankovic Rating Scale Cilj je bio utvrditi ucinak botulinum toksina tip A i zadovoljstvo u bolesnika s esencijalnim blefarospazmom. U istrazivanje je ukljuceno 12 ispitanika u dobi od 49 do 86 godina s esencijalnim blefarospazmom kojima je primijenjena terapija injekcijama botulinum toksina tip A. Ispitanicima je prije te tri tjedna nakon postupka dana anketa Blepharospasm Disability Index (BSDI) u kojoj su bila pitanja vezana za kvalitetu zivota. Dana im je i ljestvica Jankovic Rating Scale s pitanjima koja se odnose na tezinu i ucestalost simptoma. Ukupna razina poteskoca je smanjena, sto znaci da se kvaliteta zivota povecala nakon primjene botulinum toksina, a studija je pokazala da je povecanje statisticki znacajno (p = 0,003). Ozbiljnost simptoma nakon primjene botulinum toksina smanjena je, sto znaci da je doslo do smanjenja tezine poteskoca, a istrazivanje je utvrdilo statisticki znacajnu razliku (p=0,003). Ucestalost simptoma smanjena je nakon primjene botulinum toksina, a studija je pokazala statisticki znacajnu razliku (p = 0,012). Iz rezultata ovog istrazivanja mozemo utvrditi da primjenom botulinum toksina tipa A dolazi do povecanja kvalitete zivota, te da se ozbiljnost i ucestalost simptoma statisticki znacajno smanjuju. Kljucne rijeci: Botulinum toksin tip A, Esencijalni blefarospazam, Distonija, Indeks invaliditeta blefarospazma, Jankoviceva skala ocjenjivanja