학술논문
Lifestyle factors associated with inflammatory bowel disease: data from the Swiss IBD cohort study
Document Type
Report
Author
Lautenschlager, Severin A.; Barry, Mamadou Pathé; Rogler, Gerhard; Biedermann, Luc; Schreiner, Philipp; Siebenhüner, Alexander R.; Abdelrahman, Karim; Ademi, Gentiana; Aepli, Patrick; Thomas, Amman; Anderegg, Claudia; Antonino, Anca-Teodora; Archanioti, Eva; Arrigoni, Eviano; de Jong, Diana Bakker; Balsiger, Bruno; Bastürk, Polat; Bauerfeind, Peter; Becocci, Andrea; Belli, Dominique; Bengoa, José M.; Binek, Janek; Blattmann, Mirjam; Boehm, Stephan; Boldanova, Tujana; Borovicka, Jan; BellBraeggeri, Christian P.; Brand, Stephan; Brügger, Lukas; Brunner, Simon; Bühr, Patrick; Burnand, Bernard; Burk, Sabine; Burri, Emanuel; Buyse, Sophie; Cao, Dahlia-Thao; Carstens, Ove; Criblez, Dominique H.; Cunningham, Sophie; D'Angelo, Fabrizia; de Saussure, Philippe; Degen, Lukas; Delarive, Joakim; Doerig, Christopher; Dora, Barbara; Drerup, Susan; Egger, Mara; El-Wafa, Ali; Engelmann, Matthias; Ezri, Jessica; Felley, Christian; Fliegner, Markus; Fournier, Nicolas; Fraga, Montserrat; Franc, Yannick; Frei, Pascal; Frei, Remus; Fried, Michael; Froehlich, Florian; Furlano, Raoul Ivano; Garzoni, Luca; Geyer, Martin; Girard, Laurent; Girardin, Marc; Golay, Delphine; Good, Ignaz; Bigler, Ulrike Graf; Gysi, Beat; Haarer, Johannes; Halama, Marcel; Haldemann, Janine; Heer, Pius; Heimgartner, Benjamin; Helbling, Beat; Hengstler, Peter; Herzog, Denise; Hess, Cyrill; Hessler, Roxane; Heyland, Klaas; Hinterleitner, Thomas; Hirschi, Claudia; Hruz, Petr; Juillerat, Pascal; Bakker, Carolina Khalid-de; Kayser, Stephan; Keller, Céline; Knellwolf-Grieger, Christina; Knoblauch, Christoph; Köhler, Henrik; Koller, Rebekka; Krieger-Grübel, Claudia; Künzler, Patrizia; Kusche, Rachel; Lehmann, Frank Serge; Macpherson, Andrew; Maillard, Michel H.; Manz, Michael; Marot, Astrid; Meier, Rémy; Meyenberger, Christa; Meyer, Pamela; Michetti, Pierre; Misselwitz, Benjamin; Mosler, Patrick; Mottet, Christian; Müller, Christoph; Müllhaupt, Beat; Musso, Leilla; Neagu, Michaela; Nichita, Cristina; Niess, Jan; Nydegger, Andreas; Obialo, Nicole; Ollo, Diana; Oropesa, Cassandra; Peter, Ulrich; Peternac, Daniel; Petit, Laetitia Marie; Pittet, Valérie; Pohl, Daniel; Porzner, Marc; Preissler, Claudia; Raschle, Nadia; Rentsch, Ronald; Restellini, Alexandre; Restellini, Sophie; Richterich, Jean-Pierre; Ris, Frederic; Risti, Branislav; Ritz, Marc Alain; Röhrich, Nina; Rossel, Jean-Benoît; Rueger, Vanessa; Rusticeanu, Monica; Sagmeister, Markus; Saner, Gaby; Sauter, Bernhard; Sawatzki, Mikael; Scharl, Michael; Schelling, Martin; Schibli, Susanne; Schlauri, Hugo; Schluckebier, Dominique; Schmid, Daniela; Schmid-Uebelhart, Sybille; Schnegg, Jean-François; Schoepfer, Alain; Seematter, Vivianne; Seibold, Frank; Seirafi, Mariam; Semadeni, Gian-Marco; Senning, Arne; Sokollik, Christiane; Sommer, Joachim; Spalinger, Johannes; Spangenberger, Holger; Stadler, Philippe; Staub, Peter; Staudenmann, Dominic; Stenz, Volker; Steuerwald, Michael; Straumann, Alex; Strebel, Bruno; Stulz, Andreas; Sulz, Michael; Tatu, Aurora; Tempia-Caliera, Michela; Thorens, Joël; Truninger, Kaspar; Tutuian, Radu; Urfer, Patrick; Vavricka, Stephan; Viani, Francesco; Vögtlin, Jürg; Känel, Roland Von; Vouillamoz, Dominique; Vulliamy, Rachel; Wiesel, Paul; Wiest, Reiner; Wöhrle, Stefanie; Zamora, Samuel; Zander, Silvan; Wylie, Tina; Zeitz, Jonas; Zimmermann, Dorothee
Source
BMC Gastroenterology. March 12, 2023, Vol. 23 Issue 1
Subject
Language
English
ISSN
1471-230X
Abstract
Author(s): Severin A. Lautenschlager[sup.1] , Mamadou Pathé Barry[sup.2] , Gerhard Rogler[sup.1] , Luc Biedermann[sup.1] , Philipp Schreiner[sup.1] , Alexander R. Siebenhüner[sup.1,3] , Karim Abdelrahman[sup.] , Gentiana Ademi[sup.] , Patrick Aepli[sup.] [...]
Background Various environmental risk factors have been associated with the pathogenesis of inflammatory bowel disease. In this study we aimed to identify lifestyle factors that affect the onset of Crohn's disease and ulcerative colitis. Methods 2294 patients from the Swiss IBD Cohort Study received a questionnaire regarding physical activity, nutritional habits and status of weight. In addition, a control group was formed comprising patients' childhood friends, who grew up in a similar environment. Results Overall, 1111 questionnaires were returned (response rate: 48.4%). Significantly more patients with inflammatory bowel disease reported no regular practice of sport during childhood and beginning of adulthood compared to the control group (p = 0.0001). No association between intake of refined sugar and onset of inflammatory bowel disease was observed. More patients with Crohn's disease compared to ulcerative colitis and controls suffered from overweight during childhood (12.8% vs. 7.7% and 9.7%, respectively; p = 0.027). Conclusions Our study underlines the relevance of environmental factors in the development of inflammatory bowel disease. Our results imply a protective effect of physical activity regarding the onset of inflammatory bowel disease. Keywords: Inflammatory bowel disease, Environmental factors, Swiss IBD cohort study, Nutrition, Physical activity
Background Various environmental risk factors have been associated with the pathogenesis of inflammatory bowel disease. In this study we aimed to identify lifestyle factors that affect the onset of Crohn's disease and ulcerative colitis. Methods 2294 patients from the Swiss IBD Cohort Study received a questionnaire regarding physical activity, nutritional habits and status of weight. In addition, a control group was formed comprising patients' childhood friends, who grew up in a similar environment. Results Overall, 1111 questionnaires were returned (response rate: 48.4%). Significantly more patients with inflammatory bowel disease reported no regular practice of sport during childhood and beginning of adulthood compared to the control group (p = 0.0001). No association between intake of refined sugar and onset of inflammatory bowel disease was observed. More patients with Crohn's disease compared to ulcerative colitis and controls suffered from overweight during childhood (12.8% vs. 7.7% and 9.7%, respectively; p = 0.027). Conclusions Our study underlines the relevance of environmental factors in the development of inflammatory bowel disease. Our results imply a protective effect of physical activity regarding the onset of inflammatory bowel disease. Keywords: Inflammatory bowel disease, Environmental factors, Swiss IBD cohort study, Nutrition, Physical activity