학술논문
An improved joint non-negative matrix factorization for identifying surgical treatment timing of neonatal necrotizing enterocolitis
RESEARCH ARTICLE: TRANSLATIONAL AND CLINICAL RESEARCH
RESEARCH ARTICLE: TRANSLATIONAL AND CLINICAL RESEARCH
Document Type
Report
Author
Source
Bosnian Journal of Basic Medical Sciences. November 2022, Vol. 22 Issue 6, p972, 10 p.
Subject
Language
English
ISSN
1512-8601
Abstract
INTRODUCTION Neonatal necrotizing enterocolitis (NEC) is one of the causes of neonatal death. Surviving newborns are likely to have intestinal stenosis, short bowel syndrome, and even short bowel syndrome. There [...]
Neonatal necrotizing enterocolitis is a severe neonatal intestinal disease. Timely, the identification of surgical indications is essential for newborns to seek the best time for treatment and improve prognosis. This paper attempts to establish an algorithm model based on multimodal clinical data to determine the features of surgical indications and construct an auxiliary diagnosis model. The proposed algorithm adds hypergraph constraints on the two modal data based on Joint Non-negative Matrix Factorization, aiming to mine the higher-order correlations of the two data features. In addition, the adjacency matrix of the two kinds of data is used as a network regularization constraint to prevent overfitting. Orthogonal and L1-norm regulations were introduced to avoid feature redundancy and perform feature selection, respectively, and confirmed 14 clinical features. Finally, we used three classifiers, random forest, support vector machine, and logistic regression, to perform binary classification of patients requiring surgery. The results show that when the features selected by the proposed algorithm model are classified by random forest, the area under the ROC curve is 0.8, which has high prediction accuracy. KEYWORDS: Neonatal necrotizing enterocolitis; joint non-negative matrix factorization; surgical indications; multimodal clinical data
Neonatal necrotizing enterocolitis is a severe neonatal intestinal disease. Timely, the identification of surgical indications is essential for newborns to seek the best time for treatment and improve prognosis. This paper attempts to establish an algorithm model based on multimodal clinical data to determine the features of surgical indications and construct an auxiliary diagnosis model. The proposed algorithm adds hypergraph constraints on the two modal data based on Joint Non-negative Matrix Factorization, aiming to mine the higher-order correlations of the two data features. In addition, the adjacency matrix of the two kinds of data is used as a network regularization constraint to prevent overfitting. Orthogonal and L1-norm regulations were introduced to avoid feature redundancy and perform feature selection, respectively, and confirmed 14 clinical features. Finally, we used three classifiers, random forest, support vector machine, and logistic regression, to perform binary classification of patients requiring surgery. The results show that when the features selected by the proposed algorithm model are classified by random forest, the area under the ROC curve is 0.8, which has high prediction accuracy. KEYWORDS: Neonatal necrotizing enterocolitis; joint non-negative matrix factorization; surgical indications; multimodal clinical data