학술논문
Impact of Preoperative Neutrophil-Lymphocyte and Platelet-Lymphocyte Ratios on Long-Term Survival in Patients with Operable Pancreatic Ductal Adenocarcinoma
Document Type
Clinical report
Author
Source
Medical Principles and Practice. January 2023, Vol. 31 Issue 6, p586, 9 p.
Subject
Language
English
Abstract
Author(s): Lucia Romano [a]; Antonio Giuliani [a]; Chiara Tomarelli [a]; Andrea Nervini [a]; Gianni Lazzarin [a]; Beatrice Pessia [b]; Vincenzo Vicentini [b]; Francesco Carlei [a]; Mario Schietroma [a] Highlights of [...]
Background: Pancreatic ductal adenocarcinoma (PDAC) has an extremely poor prognosis. The outcomes of patients with cancer are determined not only by tumor-related factors but also by systemic inflammatory response. The objective of the study was to identify whether the preoperative neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are associated with the prognosis of PDAC of the pancreas head after curative pancreatoduodenectomy. Materials and Methods: Seventy-six patients were enrolled in this prospective, observational clinical study. The optimal NLR and PLR cut-off values were calculated using a receiver operating characteristic (ROC) curve analysis. ROC curve analysis revealed an optimal NLR and PLR cut-off point of 5.41 and 205.56, respectively. Consequently, the NLR and PRL scores were classified as NLR Keywords: Neutrophil-to-lymphocyte ratio, Platelet-to-lymphocyte ratio, Pancreatic ductal adenocarcinoma
Background: Pancreatic ductal adenocarcinoma (PDAC) has an extremely poor prognosis. The outcomes of patients with cancer are determined not only by tumor-related factors but also by systemic inflammatory response. The objective of the study was to identify whether the preoperative neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are associated with the prognosis of PDAC of the pancreas head after curative pancreatoduodenectomy. Materials and Methods: Seventy-six patients were enrolled in this prospective, observational clinical study. The optimal NLR and PLR cut-off values were calculated using a receiver operating characteristic (ROC) curve analysis. ROC curve analysis revealed an optimal NLR and PLR cut-off point of 5.41 and 205.56, respectively. Consequently, the NLR and PRL scores were classified as NLR Keywords: Neutrophil-to-lymphocyte ratio, Platelet-to-lymphocyte ratio, Pancreatic ductal adenocarcinoma