학술논문
Real world data from a multi-centre study on the effects of cilostazol on pain symptoms and walking distance in patients with peripheral arterial disease
Document Type
Report
Author
Katsiki, Niki; Tentolouris, Nikolaos; Marakomichelakis, Georgios; Richter, Dimitrios; Giannoukas, Athanasios; Koufaki, Panagiota; Papanas, Nikolaos; Alexopoulos, Ilias; Anastasiadis, Filippos; Andreadis, Evangelos; Andreopoulos, Georgios; Apostolidis, Dimitris; Christodoulou, Ioannis; Christopoulos, Ioannis; Dalaberis, Eleftherios; Daliani, Hermioni; Dimitriou, Giorgos; Dimitsikoglou, Iordanis; Dimoulis, Nikolaos; Doulgerakis, Dimitrios; Douloumpakas, Ioannis; Drakopoulou, Efrosyni; Felekis, Theodoros; Feloukas, Theodoros; Florou, Sofia; Fragakis, Dimitrios; Fregidis, Theodoros; Gakis, Panagiotis; Galanakis, Christos; Giakoumis, Antonios; Giannes, Nikolaos; Galapis, Alexandros; Gouveris, Ioannis; Groutsis, Theodoros; Grapsas, Vasileios; Grigoropoulos, Panagiotis; Iordanidis, Triantafyllos; Kazakos, Kyriakos; Kazantzi, Maria; Kapernopoulos, Haralabos; Kapetanios, Konstantinos; Karagianni, Eleni; Karakostas, Fotis; Karapiperis, Dimitris; Karotsis, Antonios; Karsanidis, Abraam; Kasfikis, Fotios; Kourouklis, Spyridon; Kourtis, Tsampikos; Kourtidou, Paraskevi; Koutsias, Stylianos; Kotsogiannis, Stavros; Lampousakis, Ioannis; Latsios, Panagiotis; Liouri, Irine; Makrygiannis, Panagiotis; Matsouki, Welcome; Bakalakou, Konstantina; Bakiris, Pavlos; Balogianni, Maria; Benis, Apostolos; Beri, Vasiliki; Beroukas, Antonios; Moysidis, Konstantinos; Nanos, Efstathios; Nikolaou, Achilleas; Dubovina, Marina; Oikonomidis, Nikolaos; Pangalos, Emmanouil; Panagoulias, Georgios; Papadopoulos, Savvas; Paraskevas, Georgios; Peroulis, Michael; Petoumenos, Vasilis; Petrogiannis, Spyridon; Pournaras, Georgios; Pourou, Helena; Prionidis, Markos; Rigas, Antonios; Rigas, Spyridon; Rigopoulos, Dimitrios; Sakellariou, Dimitrios; Sarafianos, Periklis; Svolis, Konstantinos; Seferou, Maria; Sklirou, Vasiliki; Spais, Georgios; Stathopoulos, Christos; Stavridou, Victoria; Stavrou, Ioannis; Sfiniadakis, Ioannis; Tatola, Vagia; Topalidis, Isaak; Trikkalinou, Aikaterini; Tsagarakis, Dimitrios; Tsarouchas, Panagiotis; Valkaniotis, Georgios; Varella, Maria; Vasilakakou, Stavroula; Vlachopoulou, Maria; Vouzas, Antonios; Zafeiriou, Ioannis; Zafeiris, Ioannis; Zacharopoulou, Ourania; Zinelis, Dimosthenis
Source
BMC Research Notes. December 20, 2022, Vol. 15 Issue 1
Subject
Language
English
ISSN
1756-0500
Abstract
Objective to assess the effects of cilostazol on pain-free walking distance in PAD patients with IC at 3 and 6 months in a real world, prospective, observational study. We included 1015 PAD patients presenting with IC (71.3% men, 93.5% white, mean age 69.2 [+ or -] 8.7 years). Patients were followed up for 6 months by their physicians. Results Cilostazol significantly increased pain-free walking distance by a median of 285 and 387 m at 3 and 6 months, respectively (p < 0.01 for all comparisons). This effect was significant for patients 50-74 years (but not for those aged [greater than or equal to] 75 years) and independent of smoking status, changes in physical activity, comorbidities and concomitant medication for PAD (i.e., acetylsalicylic acid and clopidogrel). Furthermore, significant reductions were observed in systolic (from 139 [+ or -] 16 to 133 [+ or -] 14 mmHg; p < 0.001) and diastolic blood pressure (from 84 [+ or -] 9 mmHg to 80 [+ or -] 10 mmHg; p < 0.001). Smoking cessation and increased physical activity were reported by the majority of participants. In conclusion, cilostazol was shown to safely decrease pain symptoms and improve pain-free walking in PAD patients with IC in a real world setting. Benefits also occurred in terms of BP and lifestyle changes. Keywords: Cilostazol, Peripheral arterial disease, Intermittent claudication, Pain-free walking distance
Author(s): Niki Katsiki[sup.1,2] , Nikolaos Tentolouris[sup.3] , Georgios Marakomichelakis[sup.4] , Dimitrios Richter[sup.5] , Athanasios Giannoukas[sup.6] , Panagiota Koufaki[sup.7] , Nikolaos Papanas[sup.8] , Ilias Alexopoulos[sup.] , Filippos Anastasiadis[sup.] , Evangelos Andreadis[sup.] [...]
Author(s): Niki Katsiki[sup.1,2] , Nikolaos Tentolouris[sup.3] , Georgios Marakomichelakis[sup.4] , Dimitrios Richter[sup.5] , Athanasios Giannoukas[sup.6] , Panagiota Koufaki[sup.7] , Nikolaos Papanas[sup.8] , Ilias Alexopoulos[sup.] , Filippos Anastasiadis[sup.] , Evangelos Andreadis[sup.] [...]