학술논문
Provision of Small-Quantity Lipid-Based Nutrient Supplements Increases Plasma Selenium Concentration in Pregnant Women in Malawi: A Secondary Outcome of a Randomized Controlled Trial
ORIGINAL RESEARCH
ORIGINAL RESEARCH
Document Type
Report
Author
Source
Current Developments in Nutrition. March 2022, Vol. 6 Issue 3, p1e, 9 p.
Subject
Language
English
ISSN
2475-2991
Abstract
Introduction Selenium is an essential micronutrient required for reproduction, thyroxine metabolism, DNA synthesis, immune function, and protection from oxidative stress (1). Maternal selenium deficiency has been associated with adverse pregnancy [...]
Background: Pregnant women in Malawi are at risk of selenium deficiency, which can have adverse effects on pregnancy outcomes. Interventions for improving selenium status are needed. Objectives: To assess the effect of provision of small-quantity lipid-based nutrient supplements (SQ-LNSs) to Malawian women during pregnancy on their plasma selenium concentrations at 36 wk of gestation. Methods: Pregnant women (16 wk of intervention (at 36 wk of gestation) and compared by intervention group. Results: At 36 wk of gestation, median (quartile 1, quartile 3) plasma selenium concentrations (micromoles per liter) were 0.96 (0.73, 1.23), 0.94 (0.78, 1.18), and 1.01 (0.85, 1.28) in the IFA, MMN, and SQ-LNS groups, respectively. Geometric mean (GM) plasma selenium concentration was 5.4% (95% CI: 1.8%, 9.0%) higher in the SQ-LNS group than in the MMN group and tended to be higher than in the IFA group (+4.2%; 95% CI: 1.0%, 7.8%). The prevalence of adjusted plasma selenium concentrations Conclusions: Provision of SQ-LNS containing selenium to pregnant women can be an effective strategy for improving their selenium status. This trial was registered at clinicaltrials.gov (identifier: NCT01239693). Curr Dev Nutr 2022;6:nzac013. Keywords: selenium status, plasma, lipid-based nutrient supplements, pregnancy, Malawi [c] The Author(s) 2022. Published by Oxford University Press on behalf of the American Society for Nutrition. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Manuscript received September 29, 2021. Initial review completed January 5, 2022. Revision accepted January 25, 2022. Published online March 7, 2022. Financial support for this work was provided by the Bill & Melinda Gates Foundation (Project Number OPP49817). The source of support had no role in the design or implementation of the study, or in data analysis or interpretation. Author disclosures: The authors report no conflicts of interest. Supplemental Figure 1, Supplemental Tables 1-2, and Supplemental Materials are available from the "Supplementary data" link in the online posting of the article and from the same link in the online table of contents at https://academic.oup.com/cdn/. Address correspondence to MJH (e-mail: mjhaskell@ucdavis.edu). Abbreviations used: AGP, [[alpha].sub.1]-acid glycoprotein; BRINDA, Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia; CRP, C-reactive protein; GM, geometric mean; GMR, geometric mean ratio; ICP-MS, inductively coupled plasma mass spectrometry; IFA, iron and folic acid; iLiNS, International Lipid-based Nutrient Supplement (Project); MMN, multiple micronutrients; SQ-LNS, small-quantity lipid-based nutrient supplement; UL, tolerable upper intake level.
Background: Pregnant women in Malawi are at risk of selenium deficiency, which can have adverse effects on pregnancy outcomes. Interventions for improving selenium status are needed. Objectives: To assess the effect of provision of small-quantity lipid-based nutrient supplements (SQ-LNSs) to Malawian women during pregnancy on their plasma selenium concentrations at 36 wk of gestation. Methods: Pregnant women (16 wk of intervention (at 36 wk of gestation) and compared by intervention group. Results: At 36 wk of gestation, median (quartile 1, quartile 3) plasma selenium concentrations (micromoles per liter) were 0.96 (0.73, 1.23), 0.94 (0.78, 1.18), and 1.01 (0.85, 1.28) in the IFA, MMN, and SQ-LNS groups, respectively. Geometric mean (GM) plasma selenium concentration was 5.4% (95% CI: 1.8%, 9.0%) higher in the SQ-LNS group than in the MMN group and tended to be higher than in the IFA group (+4.2%; 95% CI: 1.0%, 7.8%). The prevalence of adjusted plasma selenium concentrations Conclusions: Provision of SQ-LNS containing selenium to pregnant women can be an effective strategy for improving their selenium status. This trial was registered at clinicaltrials.gov (identifier: NCT01239693). Curr Dev Nutr 2022;6:nzac013. Keywords: selenium status, plasma, lipid-based nutrient supplements, pregnancy, Malawi [c] The Author(s) 2022. Published by Oxford University Press on behalf of the American Society for Nutrition. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Manuscript received September 29, 2021. Initial review completed January 5, 2022. Revision accepted January 25, 2022. Published online March 7, 2022. Financial support for this work was provided by the Bill & Melinda Gates Foundation (Project Number OPP49817). The source of support had no role in the design or implementation of the study, or in data analysis or interpretation. Author disclosures: The authors report no conflicts of interest. Supplemental Figure 1, Supplemental Tables 1-2, and Supplemental Materials are available from the "Supplementary data" link in the online posting of the article and from the same link in the online table of contents at https://academic.oup.com/cdn/. Address correspondence to MJH (e-mail: mjhaskell@ucdavis.edu). Abbreviations used: AGP, [[alpha].sub.1]-acid glycoprotein; BRINDA, Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia; CRP, C-reactive protein; GM, geometric mean; GMR, geometric mean ratio; ICP-MS, inductively coupled plasma mass spectrometry; IFA, iron and folic acid; iLiNS, International Lipid-based Nutrient Supplement (Project); MMN, multiple micronutrients; SQ-LNS, small-quantity lipid-based nutrient supplement; UL, tolerable upper intake level.