학술논문
Recent metabolomic developments for antimalarial drug discovery
Review
Review
Document Type
Academic Journal
Author
Source
Parasitology Research. December 2022, Vol. 121 Issue 12, p3351, 30 p.
Subject
Language
English
ISSN
0932-0113
Abstract
Author(s): Lúcia Mamede [sup.1], Fanta Fall [sup.2], Matthieu Schoumacher [sup.3], Allison Ledoux [sup.1], Pascal De Tullio [sup.3], Joëlle Quetin-Leclercq [sup.2], Michel Frédérich [sup.1] Author Affiliations: (1) grid.4861.b, 0000 0001 0805 [...]
Malaria is a parasitic disease that remains a global health issue, responsible for a significant death and morbidity toll. Various factors have impacted the use and delayed the development of antimalarial therapies, such as the associated financial cost and parasitic resistance. In order to discover new drugs and validate parasitic targets, a powerful omics tool, metabolomics, emerged as a reliable approach. However, as a fairly recent method in malaria, new findings are timely and original practices emerge frequently. This review aims to discuss recent research towards the development of new metabolomic methods in the context of uncovering antiplasmodial mechanisms of action in vitro and to point out innovative metabolic pathways that can revitalize the antimalarial pipeline.
Malaria is a parasitic disease that remains a global health issue, responsible for a significant death and morbidity toll. Various factors have impacted the use and delayed the development of antimalarial therapies, such as the associated financial cost and parasitic resistance. In order to discover new drugs and validate parasitic targets, a powerful omics tool, metabolomics, emerged as a reliable approach. However, as a fairly recent method in malaria, new findings are timely and original practices emerge frequently. This review aims to discuss recent research towards the development of new metabolomic methods in the context of uncovering antiplasmodial mechanisms of action in vitro and to point out innovative metabolic pathways that can revitalize the antimalarial pipeline.