학술논문

Long-Term Retinal Vascular Changes in Age-Related Macular Degeneration Measured Using Optical Coherence Tomography Angiography
Document Type
Clinical report
Source
Ophthalmic Surgery, Lasers, and Imaging Retina. October, 2022, Vol. 53 Issue 10, p529, 8 p.
Subject
University of California, Davis
Medical research -- Comparative analysis -- Physiological aspects
Medicine, Experimental -- Comparative analysis -- Physiological aspects
Vascular endothelial growth factor -- Comparative analysis -- Physiological aspects
Macular degeneration -- Physiological aspects -- Comparative analysis
Angiography -- Physiological aspects -- Comparative analysis
Tomography -- Physiological aspects -- Comparative analysis
Language
English
ISSN
2325-8160
Abstract
BACKGROUND AND OBJECTIVE: To determine if age-related macular degeneration (AMD) status affects longitudinal retinal vessel changes. PATIENTS AND METHODS: Retrospective, cohort study of 125 eyes (75 patients) with AMD, following retinal vessel density (VD) and foveal avascular zone (FAZ) measurements using optical coherence tomography angiography (OCT-A) over 24 months. RESULTS: FAZ area (P CONCLUSION: AMD eyes with GA undergo more rapid loss of retinal vessel density and FAZ enlargement over 2 years, suggesting a relationship between the retinal vasculature and AMD pathophysiology. [Ophthalmic Surg Lasers Imaging Retina 2022;53:529–536.]
As a leading global cause of blindness, age-related macular degeneration (AMD) affects about 9% of older adults and is projected to increase to 288 million people in 2040. (1–3) Although [...]