학술논문
Various Manifestations of 5-Fluorouracil Cardiotoxicity: A Multicenter Case Series and Review of Literature
Article
Article
Document Type
Academic Journal
Source
Cardiovascular Toxicology. August 2020, Vol. 20 Issue 4, p437, 6 p.
Subject
Language
English
ISSN
1530-7905
Abstract
Author(s): John D. Allison [sup.1], Toug Tanavin [sup.1], Yang Yang [sup.1], Gilad Birnbaum [sup.1], Umair Khalid [sup.1] Author Affiliations: (1) grid.39382.33, 0000 0001 2160 926X, Section of Cardiology, Department of [...]
5-Fluorouracil is a key element to the treatment of colon cancer. But it is also one of the most cardiotoxic chemotherapies, and the management of those that experience cardiotoxicity can be challenging. We present three cases of 5-FU cardiac toxicity that manifested as myocardial infarction, cardiogenic shock, and ventricular fibrillation. Additionally, we discuss the current literature regarding 5-fluorouracil cardiotoxicity mechanisms as well as management.
5-Fluorouracil is a key element to the treatment of colon cancer. But it is also one of the most cardiotoxic chemotherapies, and the management of those that experience cardiotoxicity can be challenging. We present three cases of 5-FU cardiac toxicity that manifested as myocardial infarction, cardiogenic shock, and ventricular fibrillation. Additionally, we discuss the current literature regarding 5-fluorouracil cardiotoxicity mechanisms as well as management.