학술논문
The effect of long-term past glycemic control on executive function among patients with type 2 diabetes mellitus
Original Article
Original Article
Document Type
Academic Journal
Author
Source
Diabetology International. April 2020, Vol. 11 Issue 2, p114, 7 p.
Subject
Language
English
Abstract
Author(s): Taichi Minami [sup.1] [sup.4] [sup.5], Yuzuru Ito [sup.5], Masayo Yamada [sup.1], Ryutaro Furuta [sup.2], Fuyuki Minagawa [sup.3], Kentaro Kamata [sup.2], Akiko Kameda [sup.4], Yasuo Terauchi [sup.5] Author Affiliations: (1) [...]
Objective Patients with type 2 diabetes mellitus (T2DM) show more executive dysfunction than nondiabetics. However, how long poor glycemic control affects executive function remains unclear. Thus, we aimed to investigate the relationships in a cross-sectional study. Methods We studied 118 T2DM outpatients (age, [greater than or equal to] 60 years; excluding history of stroke, dementia and severe hypoglycemia). HbA1c values were recorded every [less than or equal to] 12 weeks for [greater than or equal to] 5 years. All patients underwent verbal-fluency tests (reflecting executive function) and Mini-Mental State Examination (MMSE). The correlation between past glycemic control values and both cognitive tests scores was investigated. As markers of past glycemic control, we used average hemoglobin A1c (HbA1c) values and glycemic control variability [coefficient of variation (CV) of HbA1c values (HbA1c-CV)]. Results Verbal-fluency tests scores correlated with HbA1c-CV, but not with average HbA1c values, after adjusting for age, years of education and sex. Verbal-fluency tests scores correlated with HbA1c-CV for the past 5 years, best compared with HbA1c-CV for past < 5 years. MMSE scores were also related to only HbA1c-CV for the past 3 years in an adjustment model. Conclusions Five-year HbA1c variability affected executive function in T2DM patients, but not average HbA1c values. Long-term longitudinal studies may be required.
Objective Patients with type 2 diabetes mellitus (T2DM) show more executive dysfunction than nondiabetics. However, how long poor glycemic control affects executive function remains unclear. Thus, we aimed to investigate the relationships in a cross-sectional study. Methods We studied 118 T2DM outpatients (age, [greater than or equal to] 60 years; excluding history of stroke, dementia and severe hypoglycemia). HbA1c values were recorded every [less than or equal to] 12 weeks for [greater than or equal to] 5 years. All patients underwent verbal-fluency tests (reflecting executive function) and Mini-Mental State Examination (MMSE). The correlation between past glycemic control values and both cognitive tests scores was investigated. As markers of past glycemic control, we used average hemoglobin A1c (HbA1c) values and glycemic control variability [coefficient of variation (CV) of HbA1c values (HbA1c-CV)]. Results Verbal-fluency tests scores correlated with HbA1c-CV, but not with average HbA1c values, after adjusting for age, years of education and sex. Verbal-fluency tests scores correlated with HbA1c-CV for the past 5 years, best compared with HbA1c-CV for past < 5 years. MMSE scores were also related to only HbA1c-CV for the past 3 years in an adjustment model. Conclusions Five-year HbA1c variability affected executive function in T2DM patients, but not average HbA1c values. Long-term longitudinal studies may be required.