부산대학교 도서관

Keywords: anatomy; cerebrovascular disease; intracranial arterial diseases Abstract Background and Purpose In patients with dolichoectasia, it is uncertain how dilatation and/or elongation relate to each other. We aimed to examine the correlation between arterial diameter and length within arteries and across the circle of Willis (COW). Methods We included stroke-free participants in the Northern Manhattan Study who underwent magnetic resonance angiography. Intracranial artery diameters and lengths were obtained with semiautomated commercial software and were adjusted for head size. We first investigated the correlation between diameters and length using Pearson's correlation coefficient. We then built generalized linear models adjusted for demographics and risk factors. Results Among 1210 participants included in the analysis (mean age 71 ± 9 years, 59% women, 65% Hispanic), a larger basilar artery (BA) diameter correlated with greater BA length (r = .3), and left and right middle cerebral artery (MCA) diameters correlated with one another (r = .4). Across the COW, BA diameter correlated with MCA diameters (r = .3 for both). In adjusted analyses, MCA diameters were associated with larger posterior circulation diameters ([beta] = 0.07), MCA and BA lengths ([beta] = 0.003 and [beta] = 0.002, respectively), presence of fetal posterior cerebral artery (PCA), ([beta] = 0.11), and a complete COW ([beta] = -0.02). Similarly, BA length was associated with a fetal PCA ([beta] = 1.1), and BA diameter was associated with anterior circulation diameters ([beta] = 0.15) and presence of fetal PCA ([beta] = -0.4). Conclusions COW configuration should be considered when using arterial diameter cutoffs to define dolichoectasia. Further studies are needed to discern whether arterial diameter or length best identify individuals at risk of vascular events attributable to dolichoectasia. Article Note: Funding information NIH/NINDS R01 NS029993 (Sacco/Elkind) and NIA R01AG057709 (Gutierrez). [Correction added on 24 March 2022, after first online publication: The first three author's given names and family names were corrected in this version] Byline: Setareh Salehi Omran, Farid Khasiyev, Cen Zhang, Tatjana Rundek, Ralph L. Sacco, Clinton B. Wright, Mitchell S. V. Elkind, Jose Gutierrez