학술논문
Baseline Thrombocytopenia and Disease Severity Among COVID-19 Patients, Tibebe Ghion Specialized Hospital COVID-19 Treatment Center, Northwest Ethiopia
Document Type
Clinical report
Author
Source
Journal of Blood Medicine. June 30, 2022, Vol. 13, p315, 11 p.
Subject
Language
English
ISSN
1179-2736
Abstract
Background: Thrombocytopenia and platelet indices in COVID-19 patients were important for prompt treatment and management of the disease. Therefore, the main objective of this study was to assess the prevalence of thrombocytopenia, platelet indices, and its association with disease severity among COVID-19 patients at the Tibebe Ghion Specialized Hospital, COVID-19 treatment center, Northwest Ethiopia. Methods: A cross-sectional study was conducted among 117 conveniently recruited COVID-19 patients from March to June 2021. Sociodemographic and clinical data were collected using a structured questionnaire and checklist, respectively. The platelet parameters were analyzed by the Mindray-BC 5800 automated hematological analyzer. ANOVA and Kruskal-Wallis tests were used to compare the difference between parametric and non-parametric continuous variables, respectively. Binary logistic regression was used to identify the factors associated with thrombocytopenia. A P-value < 0.05 was defined as statistically significant for all statistical tests. Results: Among COVID-19 patients, 45, 43 and 29 were mild, moderate and severe, respectively. 65.8% of the patients were males and 34.2% were alcohol drinkers with a mean age of 50.6 [+ or -] 15.4. Moreover, 44.4% of the patients had co-morbidity. Thrombocytopenia was presented in 23.9% of the patients. It was 4.57 (95% CI: 1.30-16.07) and 6.10 (95% CI: 1.54-24.08) times more likely in the moderate and severe cases compared to mild cases, respectively. Disease severity was also associated with PDW (P-value = 0.001). Conclusion: Even though thrombocytopenia was not presented in most moderate and severe COVID-19 patients, thrombocytopenia and PDW were associated with disease severity. Keywords: COVID-19, Ethiopia, risk stratification, severity, thrombocytopenia
Background Severe acquired respiratory syndrome corona virus-2 (SARS-CoV-2) occurred in Wuhan, China in December 2019. (1) The virus has genomic similarity to the severe acute respiratory syndrome-related coronavirus and is [...]
Background Severe acquired respiratory syndrome corona virus-2 (SARS-CoV-2) occurred in Wuhan, China in December 2019. (1) The virus has genomic similarity to the severe acute respiratory syndrome-related coronavirus and is [...]