학술논문
Antipyretic and hepatoprotective potential of Tinospora crispa and investigation of possible lead compounds through in silico approaches
Document Type
Report
Author
Source
Food Science & Nutrition. December 23, 2019, Vol. 8 Issue 1, p547, 10 p.
Subject
Language
English
ISSN
2048-7177
Abstract
INTRODUCTION Plants represent a vast source of phytochemicals, some of which may potentially be applied as natural therapeutic agents to treat various diseases. Bioactive phytoconstituents include alkaloids, tannins, vitamins, nucleosides, [...]
: This research describes an investigation of the antipyretic and hepatoprotective properties of both a crude organic extract and various subfractions of the ethnomedicinal plant Tinospora crispa, using appropriate animal models. In an attempt to identify potential lead hepatoprotective compounds, in silico experiments were utilized. Antipyretic activity was assessed via the Brewer's yeast‐induced pyrexia method, while hepatoprotective effects were evaluated in a carbon tetrachloride (CCl[sub.4])‐induced animal model. A computer‐aided prediction of activity spectra for substances (PASS) model was applied to a selection of documented phytoconstituents, with the aim of identifying those compounds with most promising hepatoprotective effects. Results were analyzed using Molinspiration software. Our results showed that both the methanol extract (METC) and various subfractions (pet ether, PEFTC; n‐hexane, NHFTC; and chloroform, CFTC) significantly (p
: This research describes an investigation of the antipyretic and hepatoprotective properties of both a crude organic extract and various subfractions of the ethnomedicinal plant Tinospora crispa, using appropriate animal models. In an attempt to identify potential lead hepatoprotective compounds, in silico experiments were utilized. Antipyretic activity was assessed via the Brewer's yeast‐induced pyrexia method, while hepatoprotective effects were evaluated in a carbon tetrachloride (CCl[sub.4])‐induced animal model. A computer‐aided prediction of activity spectra for substances (PASS) model was applied to a selection of documented phytoconstituents, with the aim of identifying those compounds with most promising hepatoprotective effects. Results were analyzed using Molinspiration software. Our results showed that both the methanol extract (METC) and various subfractions (pet ether, PEFTC; n‐hexane, NHFTC; and chloroform, CFTC) significantly (p