학술논문
High Neutrophil-Lymphocyte Ratio and Delta Neutrophil-Lymphocyte Ratio Are Associated with Increased Mortality in Patients with Hepatocellular Cancer
Original Article
Original Article
Document Type
Academic Journal
Author
Source
Digestive Diseases and Sciences. June 2022, Vol. 67 Issue 6, p2666, 11 p.
Subject
Language
English
ISSN
0163-2116
Abstract
Author(s): Nicole E. Rich [sup.1], Aarthi Parvathaneni [sup.1], Ahana Sen [sup.2], Mobolaji Odewole [sup.1], Ana Arroyo [sup.1], Arjmand R. Mufti [sup.1], Thomas A. Kerr [sup.1], Lafaine Grant [sup.1], Shannan R. [...]
Background The neutrophil-lymphocyte ratio (NLR) has been proposed as a prognostic biomarker for cirrhosis and non-liver malignancies. We aimed to evaluate the prognostic value of NLR in a diverse cohort of patients with hepatocellular carcinoma (HCC). Methods We performed a retrospective study of patients diagnosed with HCC between 2008 and 2017 at two large US health systems. We used Cox proportional hazard and multivariable ordinal logistic regression models to identify factors associated with overall survival and response to first HCC treatment, respectively. Primary variables of interest were baseline NLR and delta NLR, defined as the difference between pre- and post-treatment NLR. Results Among 1019 HCC patients, baseline NLR was 200 ng/mL (45.6% vs 33.8%). Baseline NLR [greater than or equal to] 5 was independently associated with higher mortality (median survival 4.3 vs 15.1 months; adjusted HR 1.70, 95%CI 1.41-2.06), with differences in survival consistent across BCLC stages. After adjusting for baseline covariates including NLR, delta NLR > 0.26 was also independently associated with increased mortality (HR 1.42, 95%CI 1.14-1.78). In a secondary analysis, high NLR was associated with lower odds of response to HCC treatment (20.2% vs 31.6%; adjusted OR 0.55, 95%CI 0.32-0.95). Conclusions In a large Western cohort of patients with HCC, high baseline NLR and delta NLR were independent predictors of mortality. Impact NLR is an inexpensive test that may be a useful component of future HCC prognostic models.
Background The neutrophil-lymphocyte ratio (NLR) has been proposed as a prognostic biomarker for cirrhosis and non-liver malignancies. We aimed to evaluate the prognostic value of NLR in a diverse cohort of patients with hepatocellular carcinoma (HCC). Methods We performed a retrospective study of patients diagnosed with HCC between 2008 and 2017 at two large US health systems. We used Cox proportional hazard and multivariable ordinal logistic regression models to identify factors associated with overall survival and response to first HCC treatment, respectively. Primary variables of interest were baseline NLR and delta NLR, defined as the difference between pre- and post-treatment NLR. Results Among 1019 HCC patients, baseline NLR was 200 ng/mL (45.6% vs 33.8%). Baseline NLR [greater than or equal to] 5 was independently associated with higher mortality (median survival 4.3 vs 15.1 months; adjusted HR 1.70, 95%CI 1.41-2.06), with differences in survival consistent across BCLC stages. After adjusting for baseline covariates including NLR, delta NLR > 0.26 was also independently associated with increased mortality (HR 1.42, 95%CI 1.14-1.78). In a secondary analysis, high NLR was associated with lower odds of response to HCC treatment (20.2% vs 31.6%; adjusted OR 0.55, 95%CI 0.32-0.95). Conclusions In a large Western cohort of patients with HCC, high baseline NLR and delta NLR were independent predictors of mortality. Impact NLR is an inexpensive test that may be a useful component of future HCC prognostic models.