학술논문
Plasma MCP-1 and changes on cognitive function in community-dwelling older adults
Document Type
Report
Author
Sanchez-Sanchez, Juan Luis; Giudici, Kelly V.; Guyonnet, Sophie; Delrieu, Julien; Li, Yan; Bateman, Randall J.; Parini, Angelo; Vellas, Bruno; de Souto Barreto, Philipe; Vellas, Bruno; Guyonnet, Sophie; Carrié, Isabelle; Brigitte, Lauréane; Faisant, Catherine; Lala, Françoise; Delrieu, Julien; Villars, Hélène; Combrouze, Emeline; Badufle, Carole; Zueras, Audrey; Andrieu, Sandrine; Cantet, Christelle; Morin, Christophe; Van Kan, Gabor Abellan; Dupuy, Charlotte; Rolland, Yves; Caillaud, Céline; Ousset, Pierre-Jean; Lala, Françoise; Willis, Sherry; Belleville, Sylvie; Gilbert, Brigitte; Fontaine, Francine; Dartigues, Jean-François; Marcet, Isabelle; Delva, Fleur; Foubert, Alexandra; Cerda, Sandrine; Costes, Corinne; Rouaud, Olivier; Manckoundia, Patrick; Quipourt, Valérie; Marilier, Sophie; Franon, Evelyne; Bories, Lawrence; Pader, Marie-Laure; Basset, Marie-France; Lapoujade, Bruno; Faure, Valérie; Tong, Michael Li Yung; Malick-Loiseau, Christine; Cazaban-Campistron, Evelyne; Desclaux, Françoise; Blatge, Colette; Dantoine, Thierry; Laubarie-Mouret, Cécile; Saulnier, Isabelle; Clément, Jean-Pierre; Picat, Marie-Agnès; Bernard-Bourzeix, Laurence; Willebois, Stéphanie; Désormais, Iléana; Cardinaud, Noëlle; Bonnefoy, Marc; Livet, Pierre; Rebaudet, Pascale; Gédéon, Claire; Burdet, Catherine; Terracol, Flavien; Pesce, Alain; Roth, Stéphanie; Chaillou, Sylvie; Louchart, Sandrine; Sudres, Kristel; Lebrun, Nicolas; Barro-Belaygues, Nadège; Touchon, Jacques; Bennys, Karim; Gabelle, Audrey; Romano, Aurélia; Touati, Lynda; Marelli, Cécilia; Pays, Cécile; Robert, Philippe; Le Duff, Franck; Gervais, Claire; Gonfrier, Sébastien; Gasnier, Yannick; Bordes, Serge; Begorre, Danièle; Carpuat, Christian; Khales, Khaled; Lefebvre, Jean-François; El Idrissi, Samira Misbah; Skolil, Pierre; Salles, Jean-Pierre; Dufouil, Carole; Lehéricy, Stéphane; Chupin, Marie; Mangin, Jean-François; Bouhayia, Ali; Allard, Michèle; Ricolfi, Frédéric; Dubois, Dominique; Martel, Marie Paule Bonceour; Cotton, François; Bonafé, Alain; Chanalet, Stéphane; Hugon, Françoise; Bonneville, Fabrice; Cognard, Christophe; Chollet, François; Payoux, Pierre; Voisin, Thierry; Peiffer, Sophie; Hitzel, Anne; Zanca, Michel; Monteil, Jacques; Darcourt, Jacques; Molinier, Laurent; Derumeaux, Hélène; Costa, Nadège; Perret, Bertrand; Vinel, Claire; Caspar-Bauguil, Sylvie; Olivier-Abbal, Pascale; Coley, Nicola
Source
Alzheimer's Research & Therapy. January 7, 2022, Vol. 14 Issue 1
Subject
Language
English
ISSN
1758-9193
Abstract
Background Monocyte Chemoattractant Protein-1 (MCP-1), a glial-derived chemokine, mediates neuroinflammation and may regulate memory outcomes among older adults. We aimed to explore the associations of plasma MCP-1 levels (alone and in combination with [beta]-amyloid deposition--A[beta].sub.42/40) with overall and domain-specific cognitive evolution among older adults. Methods Secondary analyses including 1097 subjects (mean age = 75.3 years [+ or -] 4.4; 63.8% women) from the Multidomain Alzheimer Preventive Trial (MAPT). MCP-1 (higher is worse) and A[beta].sub.42/40 (lower is worse) were measured in plasma collected at year 1. MCP-1 in continuous and as a dichotomy (values in the highest quartile (MCP-1.sup.+)) were used, as well as a dichotomy of A[beta].sub.42/40. Outcomes were measured annually over 4 years and included the following: cognitive composite z-score (CCS), the Mini-Mental State Examination (MMSE), and Clinical Dementia Rating (CDR) sum of boxes (overall cognitive function); composite executive function z-score, composite attention z-score, Free and Cued Selective Reminding Test (FCSRT - memory). Results Plasma MCP-1 as a continuous variable was associated with the worsening of episodic memory over 4 years of follow-up, specifically in measures of free and cued delayed recall. MCP-1.sup.+ was associated with worse evolution in the CCS (4-year between-group difference: [beta] = -0.14, 95%CI = -0.26, -0.02) and the CDR sum of boxes (2-year: [beta] = 0.19, 95%CI = 0.06, 0.32). In domain-specific analyses, MCP-1.sup.+ was associated with declines in the FCSRT delayed recall sub-domains. In the presence of low A[beta].sub.42/40, MCP-1.sup.+ was not associated with greater declines in cognitive functions. The interaction with continuous biomarker values A[beta].sub.42/40x MCP-1 x time was significant in models with CDR sum of boxes and FCSRT DTR as dependent variables. Conclusions Baseline plasma MCP-1 levels were associated with longitudinal declines in overall cognitive and episodic memory performance in older adults over a 4-year follow-up. How plasma MCP-1 interacts with A[beta].sub.42/40 to determine cognitive decline at different stages of cognitive decline/dementia should be clarified by further research. The MCP-1 association on cognitive decline was strongest in those with amyloid plaques, as measured by blood plasma A[beta].sub.42/40. Keywords: MCP-1, Older adults, Alzheimer's disease, Cognitive function, Episodic memory
Author(s): Juan Luis Sanchez-Sanchez[sup.1,2] , Kelly V. Giudici[sup.1] , Sophie Guyonnet[sup.1,3] , Julien Delrieu[sup.1,3] , Yan Li[sup.4,5] , Randall J. Bateman[sup.4,5,6,7] , Angelo Parini[sup.8] , Bruno Vellas[sup.1,3] , Philipe de [...]
Author(s): Juan Luis Sanchez-Sanchez[sup.1,2] , Kelly V. Giudici[sup.1] , Sophie Guyonnet[sup.1,3] , Julien Delrieu[sup.1,3] , Yan Li[sup.4,5] , Randall J. Bateman[sup.4,5,6,7] , Angelo Parini[sup.8] , Bruno Vellas[sup.1,3] , Philipe de [...]