학술논문
SARS-CoV-2 infection increases risk of acute kidney injury in a bimodal age distribution
Document Type
Report
Author
Bjornstad, Erica C.; Cutter, Gary; Guru, Pramod; Menon, Shina; Aldana, Isabella; House, Scott; M. Tofil, Nancy; St. Hill, Catherine A.; Tarabichi, Yasir; Banner-Goodspeed, Valerie M.; Christie, Amy B.; Mohan, Surapaneni Krishna; Sanghavi, Devang; Mosier, Jarrod M.; Vadgaonkar, Girish; Walkey, Allan J.; Kashyap, Rahul; Kumar, Vishakha K.; Bansal, Vikas; Boman, Karen; Sharma, Mayank; Bogojevic, Marija; Deo, Neha; Retford, Lynn; Gajic, Ognjen; Gist, Katja M.; Mesland, Jean-Baptiste; Henin, Pierre; Petre, Hélène; Buelens, Isabelle; Gerard, Anne-Catherine; Clevenbergh, Philippe; Granado, Rolando Claure-Del; Mercado, Jose A.; Vega-Terrazas, Esdenka; Iturricha-Caceres, Maria F.; MarkotiÄ, Dragana; BoÅ¡njak, Ivana; Gavidia, Oscar Y.; Pachon, Felipe; Sanchez, Yeimy A.; KnezeviÄ, Danijel; Kovacevic, Tanja; Markic, Josko; Ardalic, Tatjana Catipovic; Polic, Branka; IviÄ, Ivo; Carev, Dominko; Glavinic, Robert; El Kassas, Mohamed; Badr, Mohamed; Tawheed, Ahmed; Yahia, Hend; Kantas, Dimitrios; Koulouras, Vasileios; Valerio, Fernando; Diaz, Oscar; Coello, Jose Luis Ramos; Perez, Guillermo; Lizardo, Ana Karen Vallecillo; Guillen, Gabina María Reyes; Soto, Helin Archaga; Kopitkó, Csaba; Bencze, Ãgnes; Méhész, István; Gerendai, Zsófia; Doddaga, Phaneendra; Chandra, Neethi; Ediga, Rekha; Basety, Shilpa; Dammareddy, Shwetha; Kasumalla, Phani Sreeharsha; Raju, Umamaheswara; Manduva, Janaki; Kolakani, Naresh; Sripathi, Shreeja; Chaitanya, Sheetal; Cherian, Anusha; Parameswaran, Sreejith; Parthiban, Magesh; Menu Priya, A.; Basavaraja, Chetak; Prabhu, Madhav; Jakati, Vishal; Rijhwani, Puneet; Jain, Ashish; Gupta, Aviral; Jaiswal, Ram Mohan; Tyagi, Ambika; Mathur, Nimish; Daga, Mradul Kumar; Agarwal, Munisha; Rohtagi, Ishan; Papani, Sridhar; Kamuram, Mahesh; Agrawal, Kamlesh Kumar; Baghel, Vijendra; Patel, Kirti Kumar; Jyothisree, Ekambaram; Petrolwala, Mukur; Ladva, Bharat; Itagaki, Yuki; Kodate, Akira; Suzuki, Reina; Takahashi, Yuki; Moriki, Koyo; Kyo, Michihito; Shigemitsu, Hidenobu; Mishima, Yuka; Nosaka, Nobuyuki; Nagashima, Michio; Al-Fares, Abdulrahman; Rodriguez-Gutierrez, Rene; Gonzalez-Gonzalez, Jose Gerardo; Salcido-Montenegro, Alejandro; Camacho-Ortiz, Adrian; Hassan-Hanga, Fatimah; Galadanci, Hadiza; Gezawa, Abubakar Shehu; Kabara, Halima M. S.; Amole, Taiwo Gboluwaga; Kabir, Halima; Haliru, Dalha Gwarzo; Ibrahim, Abdullahi S.; Asghar, Muhammad Sohaib; Syed, Mashaal; Naqvi, Syed Anosh Ali; Ishaque, Sidra; Saleem, Ali Faisal; Siddiqui, Naveed Ur Rehman; Sherali, Salima; Hashwani, Yasmin; Ishaque, Shafia; Zabolotskikh, Igor Borisovich; Zybin, Konstantin Dmitrievich; Sinkov, Sergey Vasilevich; Musaeva, Tatiana Sergeevna; Amer, Marwa Ridha; Bawazeer, Mohammed Abdullah; Dahhan, Talal I.; Kseibi, Eiad; Butt, Abid Shahzad; Khurshid, Syed Moazzum; Rabee, Muath; Abujazar, Mohammed; Alghunaim, Razan; Abualkhair, Maal; AlFirm, Abeer Turki; Alamoudi, Razan K.; AlSharif, Hassan M.; Almazwaghi, Sarah A.; Elsakran, Mohammed S.; Aid, Mohamed A.; Darwich, Mouaz A.; Hagag, Omnia M.; Ali, Salah A.; Rocacorba, Alona; Supeéa, Kathrine; Juane, Efren Ray; Medina, Jenalyn; Baduria, Jowany; Almazyad, Mohammed A.; Alarifi, Mohammed I.; Macarambon, Jara M.; Bukhari, Ahmad Abdullah; Albahrani, Hussain A.; Asfina, Kazi N.; Aldossary, Kaltham M.; Andrijevic, Ana; Gavrilovic, Srdjan; Carapic, Vladimir; Kovacevic, Pedja; Stevanovic, Predrag D.; Stojakov, Dejan S.; Ignjatovic, Duska K.; Bojic, Suzana C.; Bobos, Marina M.; Nenadic, Irina B.; Zaric, Milica S.; Djuric, Marko D.; Djukic, Vladimir R.; Teruel, Santiago Y.; Martin, Belen C.; Gharpure, Varsha P.; Raheemi, Usman; Dodd, Kenneth W.; Goodmanson, Nicholas; Hesse, Kathleen; Bird, Paige; Weinert, Chauncey; Schoenrade, Nathan; Altaher, Abdulrahman; Mayar, Esmael; Aronson, Matthew; Cooper, Tyler; Logan, Monica; Miner, Brianna; Papo, Gisele; Barry, Suzanne; Woll, Christopher; Wu, Gregory; Carrole, Erin; Burke, Kathryn; Mohammed, Mustafa; Melamed, Roman R.; Tierney, David M.; Patel, Love A.; Raj, Vino S.; Dawud, Barite U.; Mazumder, Narayana; Sidebottom, Abbey; Guenther, Alena M.; Krehbiel, Benjamin D.; Schmitz, Nova J.; Jepsen, Stacy L.; Sipsey, Lynn; Schulte, Anna; Wunderlich, Whitney; Hoyt, Cecely; Raval, Abhijit A.; Franks, Andrea; Irby, Katherine; Sanders, Ronald C.; Hefley, Glenda; Jarvis, Jennifer M.; Kharbanda, Anmol; Jhajhria, Sunil; Fyffe, Zachary; Capizzi, Stephen; Alicie, Bethany; Green, Martha; Crockarell, Lori; Drennan, Amelia; Dubuque, Kathleen; Fambrough, Tonya; Gasaway, Nikole; Krantz, Briana; Nebi, Peiman; Orga, Jan; Serfass, Margaret; Simion, Alina; Warren, Kimberly; Wheeler, Cassie; Woolman, C. J.; Ashley, Dennis W.; Adiga, Rajani; Moyer, Andrew S.; Verghese, George M.; Newsome, Andrea Sikora; Forehand, Christy C.; Bruning, Rebecca; Jones, Timothy W.; Sabov, Moldovan; Zaidi, Fatema; Tissavirasingham, Fiona; Malipeddi, Dhatri; Lutrick, Karen; Campbell, Beth Salvagio; Wilson, Cathleen; Rivers, Patrick; Brinks, Jonathan; Mongoh, Mokenge Ndiva; Gilson, Boris; Armaignac, Donna Lee; Parris, Don; Zuniga, Maria Pilar; Vargas, Ilea; Boronat, Viviana; Hutton, Anneka; Kaur, Navneet; Neupane, Prashank; Sadule-Rios, Nohemi; Rojas, Lourdes M.; Neupane, Aashish; Rivera, Priscilla; Carlos, Carlos Valle; Vincent, Gregory; Howard, Christopher M.; McBride, Cameron; Abraham, Jocelyn; Garner, Orlando; Richards, Katherine; Collins, Keegan; Antony, Preethi; Mathew, Sindhu; Danesh, Valerie C.; Dubrocq, Gueorgui; Davis, Amber L.; Hammers, Marissa J.; McGahey, Ill M.; Farris, Amanda C.; Priest, Elisa; Korsmo, Robyn; Fares, Lorie; Skiles, Kathy; Shor, Susan M.; Burns, Kenya; Dowell, Corrie A.; Gonzales, Gabriela " Hope"; Flores, Melody; Newman, Lindsay; Wilk, Debora A.; Ettlinger, Jason; Bomar, Jaccallene; Darji, Himani; Arroliga, Alejandro; Arroliga, Alejandro C.; Conzales, Gabriela Hope; Khandhar, Paras B.; Kring, Elizabeth; Bose, Somnath; Kelly, Lauren E.; Joseph, Melisa; McGourty, Marie; Capers, Krystal; Hoenig, Benjamin; Karamourtopoulos, Maria C.; Law, Anica C.; Baedorf Kassis, Elias N.; Waikar, Sushrut S.; Garcia, Michael A.; Colona, Mia; Kibbelaar, Zoe; Leong, Michael; Wallman, Daniel; Soni, Kanupriya; Maccarone, Jennifer; Gilman, Joshua; Devis, Ycar; Chung, Joseph; Paracha, Munizay; Lumelsky, David N.; DiLorenzo, Madeline; Abdurrahman, Najla; Johnson, Shelsey; Hersh, Maj Andrew M.; Wachs, C. P. T. Stephanie L.; Swigger, Brittany S.; Sattler, Capt Lauren A.; Moulton, Capt Michael N.; Miller, Aaron S.; Anderson, Edwin L.; Nagy, Rosemary; Inja, Ravali R.; Nawathe, Pooja A.; Pedraza, Isabel; Tsing, Jennifer; Carr, Karen; Chaudhary, Anila; Guglielmino, Kathleen; Tirupathi, Raghavendra; Tang, Alymer; Safi, Arshad; Green, Cindy; Newell, Jackie; Sayed, Imran A.; Brinton, John; Strom, Larisa; Chiotos, Kathleen; Blatz, Allison M.; Lee, Giyoung; Burnett, Ryan H.; Sydney, Guy I.; Traynor, Danielle M.; Nauert, Karissa; Gonzalez, Annika; Bagley, Mariel; Santpurkar, Anita; Cheruku, Sreekanth; Ahmed, Farzin; Deonarine, Christopher; Jones, Ashley; Shaikh, Mohammad-Ali; Preston, David; Chin, Jeanette; Vachharajani, Vidula; Duggal, Abhijit; Rajendram, Prabalini; Mehkri, Omar; Dugar, Siddharth; Biehl, Michelle; Sacha, Gretchen; Houltham, Stuart; King, Alexander; Ashok, Kiran; Poynter, Bryan; Beukemann, Mary; Rice, Richard; Gole, Susan; Shaner, Valerie; Conjeevaram, Adarsh; Ferrari, Michelle; Alappan, Narendrakumar; Minear, Steven; Hernandez-Montfort, Jaime; Nasim, Syed Sohaib; Sunderkrishnan, Ravi; Sahoo, Debasis; Daugherty, Steven K.; Atkinson, Sam; Shrimpton, Kelly; Ontai, Sidney; Contreras, Brian; Obinwanko, Uzoma; Amamasi, Nneka; Sharafi, Amir; Lee, Sarah; Esber, Zahia; Jinjvadia, Chetna; Waller, Christine; Kallies, Kara; Thorsen, Jonean; Fitzsimmons, Alec; Olsen, Haley; Dapul, Heda R.; Verma, Sourabh; Salas, Alan; Daube, Ariel; Korn, Michelle; Ramirez, Michelle; Rajagopalan, Logi; Santos, Laura; Santiago, Héctor Collazo; Hernandez, Ricardo Alan; Smalls, Orma; Malhotra, Atul; Husain, Abdurrahman; Zawaydeh, Qais; Steuernagle, J. H.; Davis, Steven Q.; Jovic, Valentina; Masuda, Max; Hayes, Amanda; Gossett, Kristen Lee; Nason, Jennifer; Morris, Sarah; Deans, Sarah; Houston, Stephanie; Smith, Michael; Snow, William; Liptak, Riley; Durant, Hannah; Pendleton, Valerie; Nanavati, Alay; Mrozowsk, Risa; Nag, Namrata; Brauer, Jeff; Dharmadhikari, Ashwin; Singh, Sahib; Laghi, Franco; Naeem, Ghania; Wang, Andrew; Bliden, Kevin; Rout, Amit; Barnes, Jaime; Gesheff, Martin; Thomas, Asha; Thomas, Melbin; Liendo, Alicia R.; Milosavljevic, Jovan; Abbasi, Kenan; Burley, Nicholas B.; Rapista, Nicole; Amankwah, Samuel; Poudel, Sanjay K.; Timilsina, Saroj; Sarkar, Sauradeep; Akinyosoye, Oluwasayo; Yalamanchili, Shashi K.; Moorthy, Sheena; Sugumar, Sonia; Ford, Jonathan; Taylor, Martin C.; Dunderdale, Charlotte; Henshaw, Alyssa; Brunk, Mary K.; Hagy, Jessica; Masood, Shehryar; Sridhar, Sushrutha; Gupta, Manoj K.; Oulds, Franscene E.; Nandavar, Akshay; Liu, Yuk Ming; Zavala, Sarah; Shim, Esther; Wen, Andy Y.; DaCar, Allie; Reilkoff, Ronald A.; Heneghan, Julia A.; Eichen, Sarah; Goertzen, Lexie; Rajala, Scott; Feussom, Ghislaine; Tang, Ben; Junia, Christine C.; Lichtenberg, Robert; Sidhu, Hasrat; Espinoza, Diana; Rodrigues, Shelden; Zabala, Maria Jose; Goyes, Daniela; Susheela, Ammu; Hatharaliyadda, Buddhi; Rameshkumar, Naveen; Kasireddy, Amulya; Maldonado, Genessis; Beltran, Lisseth; Chaugule, Akshata; Khan, Hassan; Patil, Namrata; Patil, Ruhi; Cartin-Ceba, Rodrigo; Sen, Ayan; Palacios, Amanda; Mahdi, Giyth M.; Tekin, Aysun; Lal, Amos; O'Horo, John C.; Deo, Neha N.; Qamar, Shahraz; Domecq, Juan Pablo; Singh, Romil; Niven, Alex; La Nou, Abigail; Mullen, Barbara; Franco, Pablo Moreno; Gnanapandithan, Karthik; Saunders, Hollie; Fleissner, Zachary; Garcia, Juan; Mateus, Alejandra Yu Lee; Yarrarapu, Siva Naga; Kaur, Nirmaljot; Giri, Abhisekh; Khan, Syed Anjum; Jain, Nitesh Kumar; Koritala, Thoyaja; Bastidas, Alexander; Orellana, Gabriela; Bierwirth, Adriana Briceno; Milazzo, Eliana; Sierra, Juan Guillermo; Dang, Thao; Nanchal, Rahul S.; Bergl, Paul A.; Peterson, Jennifer L.; Yamanaka, Travis; Barreras, Nicholas A.; Markos, Michael; Fareeduddin, Anita; Mehta, Rohan; Venkata, Chakradhar; Engemann, Miriam; Mantese, Annamarie; Perzynski, Adam; Wang, Christine; Kotekal, Dhatri; Briceno Bierwirth, Adriana C.; Orellana, Gabriela M.; Catalasan, Gerardo; Ahmed, Shohana; Matute, Carlos F.; Hamdan, Ahmad; Salinas, Ivania; Del Nogal, Genesis; Tejada, Angel; Eschler, Anna; Hejna, Mary; Lewandowski, Emily; Kusmierski, Kristen; Martin, Clare; Siddiqi, Nasar A.; Jurado, Lesly; Tincher, Lindsey; Brown, Carolyn; Sendi, Prithvi; Nadiger, Meghana; Totapally, Balagangadhar; Aulakh, Bhagat S.; Tripathi, Sandeep; Bandy, Jennifer A.; Kreps, Lisa M.; Bollinger, Dawn R.; Stienecker, Roger Scott; Melendez, Andre G.; Brunner, Tressa A.; Budzon, Sue M.; Heffernan, Jessica L.; Souder, Janelle M.; Miller, Tracy L.; Maisonneuve, Andrea G.; Redfern, Roberta E.; Shoemaker, Jessica; Micham, Jennifer; Kenney, Lynn; Naimy, Gabriel; Balcer, Holly; Utley, Sara; Bouknight, Dawn; Patel, Radha; Alfehaid, Lama; Hamarshi, Majdi; Ploetz, Jeannette; Bennett, Nick; Klindworth, Kyle; Younis, Moustafa; Mohamed, Adham; Vilella, Antonia L.; Kutner, Sara B.; Clark, Kacie; Moore, Danielle; McGuire, John K.; Rich, Deana; Zaren, Howard A.; Smith, Stephanie J.; Lewis, Grant C.; Seames, Lauren; Farlow, Cheryl; Miller, Judy; Broadstreet, Gloria; Martinez, Anthony; Allison, Micheal; Mittal, Aniket; Ruiz, Rafael; Skaanland, Aleta; Ross, Robert; Patel, Umang; Hodge, Jordesha; Patel, Krunal Kumar; Dalal, Shivani; Kavani, Himanshu; Joseph, Sam; Mohabir, Paul K.; O'Brien, Connor G.; Dasani, Komal; Marx, William; Amzuta, Ioana; Choudhry, Asad J.; Azam, Mohammad T.; Gupta, Neha; Jones, Tracy L.; Ayers, Shonda C.; Harrell, Amy B.; Brown, Brent R.; Bhalala, Utpal S.; Kuehne, Joshua; Garcia, Melinda; Beebe, Morgan; Herrera, Heather; Fiack, Chris; Guo, Stephanie; Vawer, May; Blackburn, Beth; Belden, Katherine A.; Baram, Michael; Weber, Devin M.; DePaola, Rosalie; Xia, Yuwei; Carter, Hudson; Tolley, Aaron; Barletta, Mary; Steele, Mark; Kemble, Laurie; Denson, Joshua L.; Gillet, A. Scott; Brown, Margo; Stevens, Rachael; Wetherbie, Andrew; Tea, Kevin; Moore, Mathew; Sines, Benjamin J.; Bice, Thomas J.; Dy, Rajany V.; Iardino, Alfredo; Sharma, Jill; Christopher, Julia; Mashina, Marwan; Patel, Kushal; Tofil, Nancy M.; Meena, Nikhil K.; Caceres, Jose D.; Epps, Sarenthia M.; Goraya, Harmeen; Besett, Kelsey R.; James, Ryan; Abusalem, Lana Y.; Patel, Akash K.; Hasan, Lana S.; Stulce, Casey W.; Chong, Grace; Ghavam, Ahmeneh; Mayampurath, Anoop; Gomaa, Dina; Goodman, Michael; Wakefield, Devin; Spuzzillo, Anthony; Shinn, John O.; McGonagill, Patrick W.; Galet, Colette; Hubbard, Janice; Wang, David; Allan, Lauren; Badheka, Aditya; Chegondi, Madhuradhar; Nazir, Usman; Rampon, Garrett; Riggle, Jake; Dismang, Nathan; Akca, Ozan; Lenhardt, Rainer; Cavallazzi, Rodrigo S.; Jerde, Ann; Black, Alexa; Polidori, Allison; Griffey, Haily; Winkler, Justin; Brenzel, Thomas; Park, Pauline; Admon, Andrew; Hanna, Sinan; Chanderraj, Rishi; Pliakas, Maria; Wolski, Ann; Cirino, Jennifer; Dandachi, Dima; Regunath, Hariharan; Camazine, Maraya N.; Geiger, Grant. E.; Njai, Abdoulie O.; Saad, Baraa M.; Shah, Faraaz Ali; Chuan, Byron; Rawal, Sagar L.; Piracha, Manal; Tonna, Joseph E.; Levin, Nicholas M.; Suslavich, Kayte; Tsolinas, Rachel; Fica, Zachary T.; Skidmore, Chloe R.; Stapleton, Renee D.; Dixon, Anne E.; Johnson, Olivia; Ardren, Sara S.; Burns, Stephanie; Raymond, Anna; Gonyaw, Erika; Hodgdon, Kevin; Housenger, Chloe; Lin, Benjamin; McQuesten, Karen; Pecott-Grimm, Heidi; Sweet, Julie; Ventrone, Sebastian; Akhter, Murtaza; Rahman, Rania Abdul; Mulrow, Mary; Wilfong, Erin M.; Vela, Kelsi; Kashiouris, Markos G.; Gal, Tamas; Mahashabde, Manasi; Vagonis, Alexandra; Uber, Rebecca; Mahmud, Haseeb; Leightle, Stefan; Zhang, Zoe; Vissichelli, Nicole; Karam, Oliver; O'Meara, Alia; De Carvalho, Heloisa; Rocawich, Katie; Khanna, Ashish K.; Harris, Lynne; Cusson, Bruce; Fowler, Jacob; Vaneenenaam, David; McKinney, Glen; Udoh, Imoh; Johnson, Kathleen; Lyons, Patrick G.; Michelson, Andrew P.; Haluf, Sara S.; Lynch, Lauren M.; Nguyen, Nguyet M.; Steinberg, Aaron; Pattan, Vishwanath; Papke, Jessica; Jimada, Ismail; Mhid, Nida; Chakola, Samuel
Source
BMC Nephrology. February 11, 2022, Vol. 23 Issue 1
Subject
Language
English
ISSN
1471-2369
Abstract
Author(s): Erica C. Bjornstad[sup.1] , Gary Cutter[sup.2] , Pramod Guru[sup.3] , Shina Menon[sup.4] , Isabella Aldana[sup.1] , Scott House[sup.1] , Nancy M. Tofil[sup.5] , Catherine A. St. Hill[sup.6] , Yasir [...]
Background Hospitalized patients with SARS-CoV2 develop acute kidney injury (AKI) frequently, yet gaps remain in understanding why adults seem to have higher rates compared to children. Our objectives were to evaluate the epidemiology of SARS-CoV2-related AKI across the age spectrum and determine if known risk factors such as illness severity contribute to its pattern. Methods Secondary analysis of ongoing prospective international cohort registry. AKI was defined by KDIGO-creatinine only criteria. Log-linear, logistic and generalized estimating equations assessed odds ratios (OR), risk differences (RD), and 95% confidence intervals (CIs) for AKI and mortality adjusting for sex, pre-existing comorbidities, race/ethnicity, illness severity, and clustering within centers. Sensitivity analyses assessed different baseline creatinine estimators. Results Overall, among 6874 hospitalized patients, 39.6% (n = 2719) developed AKI. There was a bimodal distribution of AKI by age with peaks in older age ([greater than or equai to]60 years) and middle childhood (5-15 years), which persisted despite controlling for illness severity, pre-existing comorbidities, or different baseline creatinine estimators. For example, the adjusted OR of developing AKI among hospitalized patients with SARS-CoV2 was 2.74 (95% CI 1.66-4.56) for 10-15-year-olds compared to 30-35-year-olds and similarly was 2.31 (95% CI 1.71-3.12) for 70-75-year-olds, while adjusted OR dropped to 1.39 (95% CI 0.97-2.00) for 40-45-year-olds compared to 30-35-year-olds. Conclusions SARS-CoV2-related AKI is common with a bimodal age distribution that is not fully explained by known risk factors or confounders. As the pandemic turns to disproportionately impacting younger individuals, this deserves further investigation as the presence of AKI and SARS-CoV2 infection increases hospital mortality risk. Keywords: COVID-19, AKI, Age-spectrum, Hospitalization
Background Hospitalized patients with SARS-CoV2 develop acute kidney injury (AKI) frequently, yet gaps remain in understanding why adults seem to have higher rates compared to children. Our objectives were to evaluate the epidemiology of SARS-CoV2-related AKI across the age spectrum and determine if known risk factors such as illness severity contribute to its pattern. Methods Secondary analysis of ongoing prospective international cohort registry. AKI was defined by KDIGO-creatinine only criteria. Log-linear, logistic and generalized estimating equations assessed odds ratios (OR), risk differences (RD), and 95% confidence intervals (CIs) for AKI and mortality adjusting for sex, pre-existing comorbidities, race/ethnicity, illness severity, and clustering within centers. Sensitivity analyses assessed different baseline creatinine estimators. Results Overall, among 6874 hospitalized patients, 39.6% (n = 2719) developed AKI. There was a bimodal distribution of AKI by age with peaks in older age ([greater than or equai to]60 years) and middle childhood (5-15 years), which persisted despite controlling for illness severity, pre-existing comorbidities, or different baseline creatinine estimators. For example, the adjusted OR of developing AKI among hospitalized patients with SARS-CoV2 was 2.74 (95% CI 1.66-4.56) for 10-15-year-olds compared to 30-35-year-olds and similarly was 2.31 (95% CI 1.71-3.12) for 70-75-year-olds, while adjusted OR dropped to 1.39 (95% CI 0.97-2.00) for 40-45-year-olds compared to 30-35-year-olds. Conclusions SARS-CoV2-related AKI is common with a bimodal age distribution that is not fully explained by known risk factors or confounders. As the pandemic turns to disproportionately impacting younger individuals, this deserves further investigation as the presence of AKI and SARS-CoV2 infection increases hospital mortality risk. Keywords: COVID-19, AKI, Age-spectrum, Hospitalization