부산대학교 도서관

Purpose: Tarlov cysts (TCs) are dilated nerve root sheaths originating from increased cerebrospinal pressure. Patients with TCs often complain of neuropathic pain and paresthesia. The aim of this study was to retrospectively review intraepidermal nerve fiber density (IENFD) and electrodiagnostic (EDX) data from TC patients. Patients and Methods: Lower leg skin biopsy results and EDX data from the L2--S4 myotomes of patients with lumbar or sacral TCs [greater than or equal to]8 mm were retrieved from a database of a physical medicine clinic. Patients with compressive pathology, diabetes mellitus and chemotherapy were excluded. Results: IENFD data from 17 patients and EDX data from 24 patients with TCs [greater than or equal to]8 mm were available. The mean age was 47 [+ or -] 10y, and 83% were women. In 82% of patients, the IENFD was below the 5th percentile by age and sex. EDX showed increased Hoffmann refex latencies in 25%, increased anal refex latencies in 95%, and a patchy distribution of neurogenic motor unit potentials in 100%. More than 50% of needle EMG abnormalities appeared in myotomes unrelated to the location of the TCs. Conclusion: Small- and/or large-fiber neuropathy was documented in a significant proportion of patients with TCs. The novel findings may add to the understanding of the mechanisms involved in symptomatic TCs. We propose that pathologically elevated cerebrospinal fluid pressure not only dilates some of the nerve root sheaths to form TCs but also potentially damages axons in nondilated nerve root sheaths and neurons in the dorsal root ganglia. Keywords: perineural cysts, skin biopsies, radicular pain, anal refex, nerve conduction studies, fibromyalgia
Introduction Tarlov cysts (TCs) or perineural cysts are dilations of nerve root sheaths near the dorsal root ganglion containing nerve roots and neurons. The dilations are assumed to originate from [...]