학술논문
Identification of 19 Novel Hepatitis C Virus Subtypes-Further Expanding HCV Classification
MAJOR ARTICLE
MAJOR ARTICLE
Document Type
Clinical report
Author
Source
Open Forum Infectious Diseases. March 2019, Vol. 6 Issue 3
Subject
Language
English
ISSN
2328-8957
Abstract
Hepatitis C virus (HCV) has a high degree of genetic diversity, and the number of HCV genotypes and subtypes continues to increase. Until recently, HCV was classified into 7 distinct [...]
Background. Hepatitis C virus (HCV) is currently classified into 8 genotypes and 86 subtypes. The objective of this study was to characterize novel HCV subtypes and to investigate the impact of subtypes on treatment outcome. Methods. Full-genome sequencing was performed on HCV plasma samples with Results. A total of 14 653 patients with GT1-6 HCV infection were enrolled in clinical studies of sofosbuvir-based regimens. For the majority of the patients, a specific subtype could be assigned based on a close genetic relationship to previously described subtypes. However, for 19 patients, novel subtypes were identified with Conclusions. Nineteen novel HCV subtypes were identified, suggesting an even greater genetic diversity of HCV subtypes than previously recognized. Keywords. direct-acting antivirals (DAAs); phylogenetic analysis; resistance-associated substitutions (RAS); sofosbuvir; velpatasvir; voxilaprevir.
Background. Hepatitis C virus (HCV) is currently classified into 8 genotypes and 86 subtypes. The objective of this study was to characterize novel HCV subtypes and to investigate the impact of subtypes on treatment outcome. Methods. Full-genome sequencing was performed on HCV plasma samples with Results. A total of 14 653 patients with GT1-6 HCV infection were enrolled in clinical studies of sofosbuvir-based regimens. For the majority of the patients, a specific subtype could be assigned based on a close genetic relationship to previously described subtypes. However, for 19 patients, novel subtypes were identified with Conclusions. Nineteen novel HCV subtypes were identified, suggesting an even greater genetic diversity of HCV subtypes than previously recognized. Keywords. direct-acting antivirals (DAAs); phylogenetic analysis; resistance-associated substitutions (RAS); sofosbuvir; velpatasvir; voxilaprevir.