부산대학교 도서관

Objective The prevalence of anemia has remained high among Indian adolescent girls over the past decade, despite the ongoing iron and folic acid (IFA) supplementation program. This study was conducted to assess the impact of daily supplementation of a package of IFA with vitamin B.sub.12 on hemoglobin levels among adolescent girls. Methods A community-based cluster-randomized trial was conducted in the rural block of Faridabad District, Haryana, India in the year 2017. A total of 760 adolescent girls in the age group of 12-19 years with mild and moderate anemia were selected from government schools. Daily-supervised administration of iron and folic acid was conducted for 90 days: experimental group--IFA (iron (60 mg), folic acid (500) mcg), and cyanocobalamin (1000 mcg), control group--IFA and placebo. Hemoglobin, serum ferritin, and vitamin B.sub.12 levels were assessed at baseline and endline. Results Two-hundred adolescent girls completed 90 doses of daily supplementation. The mean hemoglobin (experimental group: 1.3 [plus or minus] 1.0 g/dL, control group: 1.6 [plus or minus] 1.2 g/dL, P = 0.004) and ferritin levels (experimental group: 18.6 [plus or minus] 31.5 ng/mL, control group: 18.8 [plus or minus] 35.0 ng/mL, P = 0.188) increased in both the control and experiment groups. Serum vitamin B.sub.12 deficiency significantly reduced to 2.5% in the experimental group and ferritin deficiency alleviated in more than 96% of the girls post intervention. Conclusions Daily supplementation of IFA with/without vitamin B.sub.12 for 90 days eliminated iron, vitamin B.sub.12 deficiency and reduced the overall proportion of anemia by 53.5%. However, addition of vitamin B.sub.12 to IFA supplementation had no impact on improving the hemoglobin levels among adolescent girls. The present study does not recommend provision of vitamin B.sub.12 for prevention and treatment of anemia in this population group.
Author(s): Aakriti Gupta [sup.1] , Shashi Kant [sup.2] , Lakshmy Ramakrishnan [sup.3] , Ravindra Mohan Pandey [sup.4] , Ritika Khandelwal [sup.1] , Umesh Kapil [sup.1] , Harshpal Singh Sachdev [sup.5] [...]