학술논문
Ten millennia of hepatitis B virus evolution
PALEOGENOMICS
PALEOGENOMICS
Document Type
Academic Journal
Author
Kocher, Arthur; Papac, Luka; Barquera, Rodrigo; Key, Felix M.; Spyrou, Maria A.; Hiibler, Ron; Rohrlach, Adam B.; Aran, Franziska; Stahl, Raphaela; Wissgott, Antje; Bommel, Florian van; Pfefferkom, Maria; Mittnik, Alissa; Villalba-Mouco, Vanessa; Neumann, Gunnar U.; Rivollat, Made; Loosdrecht, Marieke S. van de; Majander, Kerttu; Tukhbatova, Rezeda I.; Musralina, Lyazzat; Ghalichi, Ayshin; Penske, Sandra; Sabin, Susanna; Michel, Megan; Gretzinger, Joscha; Nelson, Elizabeth A.; Ferraz, Tiago; Nagele, Kathrin; Parker, Cody; Keller, Marcel; Guevara, Evelyn K.; Feldman, Michal; Eisenmann, Stefanie; Skourtanioti, Eirini; Giffin, Karen; Gnecchi-Ruscone, Guido Alberto; Friederich, Susanne; Schimmenti, Vittoria; Khartanovich, Valery; Karapetian, Marina K.; Chaplygin, Mikhail S.; Kufterin, Vladimir V.; Khokhlov, Aleksandr A.; Chizhevsky, Andrey A.; Kochkina, Anna F.; Tejedor-Rodriguez, Cristina; Garcia-Lagran, migo Martfnez de; Arcusa-Magallon, Hector; Garrido-Pena, Rafael; Royo-Guillen, Jose Ignacio; Novacek, Jan; Rottier, Stephane; Kacki, Sacha; Saintot, Sylvie; Kaverzneva, Elena; Belinskiy, Andrej B.; Veleminsky, Petr; Limbursky, Petr; Kostka, Michal; Loe, Louise; Popescu, Elizabeth; Clarke, Rachel; Lyons, Alice; Mortimer, Richard; Sajantila, Antti; Armas, Yadira Chinique de; Godoy, Silvia Teresita Hernandez; I. Hernandez-Zaragoza, Diana; Pearson, Jessica; Binder, Didier; Lefranc, Philippe; Kantorovich, Anatoly R.; Maslov, Vladimir E.; Lai, Luca; Zoledziewska, Magdalena; Beckett, Jessica F.; Langova, Michaela; Danielisova, Alzbeta; Ingman, Tara; Atienzar, Gabriel Garcia; Ibaftez, Maria Paz de Miguel; Romero, Alejandro; Sperduti, Alessandra; Beckett, Sophie; Zilivinskaya, Emma D.; V. Vasil'ev, Dmitry; Heyking, Kristin von; Burger, Richard L.; Salazar, Lucy C.; Amkreutz, Luc; Navruzbekov, Masnav; Rosenstock, Eva; Alonso-Fernindez, Carmen; Slavchev, Vladimir; Kalmykov, Alexey A.; Atabiev, Biaslan Ch.; Batieva, Elena; Calmet, Micaeia Alvarez; Llamas, Bastien; Schultz, Michael; KrauB, Raiko; Jimenez-Echevarria, Javier; Francken, Michael; Shnaider, Svetlana; Altena, Eveline; Vijver, Katrien Van de; Fehren-Schmitz, Lars; Tung, Tiffiny A.; Losch, Sandra; Dobrovolskaya, Maria; Makarov, Nikolaj; Read, Chris; Twest, Melanie Van; Sagona, Claudia; Ramsl, Peter C.; Akar, Murat; Yener, K. Aslihan; Ballestero, Eduardo Carmona; Cucca, Francesco; Mazzarello, Vittorio; Utrilla, Pilar; Rademaker, Kurt; Fernandez-Dominguez, Eva; Baird, Douglas; Semal, Patrick; Marquez-Morfin, Lourdes; Roksandic, Mirjana; Steiner, Hubert; Salazar-Garcia, Domingo Carlos; Shishlina, Natalia; Erda, Yilmaz Selim; Hallgren, Fredrik; Boyadzhiev, Yavor; Boyadzhiev, Kamen; KiiBner, Mario; Sayei, Duncan; Onkamo, Paivi; Skeates, Robin; Rojo-Guerra, Manuel; Buzhilova, Alexandra; Khussainova, Elmira; Djansugurova, Leyla B.; Beisenov, Arman Z.; Samashev, Zainolla; Massy, Ken; Mannino, Marcello; Moiseyev, Vyacheslav; Mannermaa, Kristiina; Balanovsky, Oleg; Deguilloux, Marie-France; Reinhold, Sabine; Hansen, Svend; Kitov, Egor P.; Dobes, Miroslav; Ernee, Michal; Meller, Harald; Alt, Kurt W.; Priifer, Kay; Warinner, Christina; Schiffels, Stephan; Stockhammer, Philipp W.; Bos, Kirsten; Posth, Cosimo; Herbig, Alexander; Haak, Wolfgang; Krause, Johannes; Kuhnert, Denise
Source
Science. October 8, 2021, Vol. 374 Issue 6564, p182, 7 p.
Subject
Language
English
ISSN
0036-8075
Abstract
Hepatitis B virus (HBV) has been infecting humans for millennia and remains a global health problem, but its past diversity and dispersal routes are largely unknown. We generated HBV genomic data from 137 Eurasians and Native Americans dated between -10,500 and -400 years ago. We date the most recent common ancestor of all HBV lineages to between -20,000 and 12,000 years ago, with the virus present in European and South American hunter-gatherers during the early Holocene. After the European Neolithic transition, Mesolithic HBV strains were replaced by a lineage likely disseminated by early farmers that prevailed throughout western Eurasia for -4000 years, declining around the end of the 2nd millennium BCE. The only remnant of this prehistoric HBV diversity is the rare genotype G, which appears to have reemerged during the HIV pandemic.