학술논문
Intensive Blood Pressure Lowering in Patients with Moderate to Severe Grade Acute Cerebral Hemorrhage: Post Hoc Analysis of Antihypertensive Treatment of Acute Cerebral Hemorrhage (ATACH)-2 Trial
Document Type
Report
Source
Cerebrovascular Diseases. July 1, 2020, Vol. 49 Issue 3, p244, 9 p.
Subject
Language
English
ISSN
1015-9770
Abstract
Objective: To study the effect of intensive blood pressure reduction in patients with moderate to severe intracerebral hemorrhage (ICH) within the subjects recruited in Antihypertensive Treatment of Acute Cerebral Hemorrhage 2 trial. Design: Randomized, multicenter, 2 group, open-label clinical trial. Setting: A total of 110 sites in the USA, Japan, China, Taiwan, South Korea, and Germany. Patients: A total of 1,000 patients underwent randomization from May 2011 till September 2015. Interventions: We analyzed the effect of intensive (goal 110-139 mm Hg) over standard (goal 140-179 mm Hg) systolic blood pressure (SBP) reduction using intravenous nicardipine within 4.5 h of symptom onset in moderate to severe grade subjects with ICH in a non-prespecified analysis. Moderate to severe grade was defined by Glasgow Coma Scale score Keywords: Intracerebral hemorrhage, Clinical trial, Death or disability, Systolic blood pressure, Hematoma expansion
Author(s): Adnan I. Qureshi (corresponding author) [a]; Lydia D. Foster [b]; Iryna Lobanova [a]; Wei Huang [a]; Jose I. Suarez [c] Introduction The Antihypertensive Treatment of Acute Cerebral Hemorrhage (ATACH)-2 [...]
Author(s): Adnan I. Qureshi (corresponding author) [a]; Lydia D. Foster [b]; Iryna Lobanova [a]; Wei Huang [a]; Jose I. Suarez [c] Introduction The Antihypertensive Treatment of Acute Cerebral Hemorrhage (ATACH)-2 [...]