학술논문
Abdominal pain in patients with inflammatory bowel disease: association with single-nucleotide polymorphisms prevalent in irritable bowel syndrome and clinical management
Document Type
Report
Author
Ledergerber, Martina; Lang, Brian M.; Heinrich, Henriette; Biedermann, Luc; Begré, Stefan; Zeitz, Jonas; Krupka, Niklas; Rickenbacher, Andreas; Turina, Matthias; Greuter, Thomas; Schreiner, Philipp; Roth, René; Siebenhüner, Alexander; Vavricka, Stephan R.; Rogler, Gerhard; Beerenwinkel, Niko; Misselwitz, Benjamin; Anderegg, Claudia; Bauerfeind, Peter; Beglinger, Christoph; Belli, Dominique; Bengoa, José M.; Bigler, Beat; Binek, Janek; Blattmann, Mirjam; Boehm, Stephan; Borovicka, Jan; Braegger, Christian P.; Brunner, Nora; Bühr, Patrick; Burnand, Bernard; Burri, Emanuel; Buyse, Sophie; Cremer, Matthias; Criblez, Dominique H.; de Saussure, Philippe; Degen, Lukas; Delarive, Joakim; Doerig, Christopher; Dora, Barbara; Dorta, Gian; Egger, Mara; Ehmann, Tobias; El-Wafa, Ali; Engelmann, Matthias; Ezri, Jessica; Felley, Christian; Fliegner, Markus; Fournier, Nicolas; Fraga, Montserrat; Frei, Pascal; Frei, Remus; Fried, Michael; Froehlich, Florian; Funk, Christian; Furlano, Raoul Ivano; Gallot-Lavallée, Suzanne; Geyer, Martin; Girardin, Marc; Golay, Delphine; Grandinetti, Tanja; Gysi, Beat; Haack, Horst; Haarer, Johannes; Helbling, Beat; Hengstler, Peter; Herzog, Denise; Hess, Cyrill; Heyland, Klaas; Hinterleitner, Thomas; Hiroz, Philippe; Hirschi, Claudia; Hruz, Petr; Iwata, Rika; Jost, Res; Juillerat, Pascal; Brondolo, Vera Kessler; Knellwolf, Christina; Knoblauch, Christoph; Köhler, Henrik; Koller, Rebekka; Krieger-Grübel, Claudia; Kullak-Ublick, Gerd; Künzler, Patrizia; Landolt, Markus; Lange, Rupprecht; Lehmann, Frank Serge; Macpherson, Andrew; Maerten, Philippe; Maillard, Michel H.; Manser, Christine; Manz, Michael; Marbet, Urs; Marx, George; Matter, Christoph; McLin, Valérie; Meier, Rémy; Mendanova, Martina; Meyenberger, Christa; Michetti, Pierre; Moradpour, Darius; Morell, Bernhard; Mosler, Patrick; Mottet, Christian; Müller, Christoph; Müller, Pascal; Müllhaupt, Beat; Münger-Beyeler, Claudia; Musso, Leilla; Nagy, Andreas; Neagu, Michaela; Nichita, Cristina; Niess, Jan; Noël, Natacha; Nydegger, Andreas; Obialo, Nicole; Oneta, Carl; Oropesa, Cassandra; Peter, Ueli; Peternac, Daniel; Petit, Laetitia Marie; Piccoli-Gfeller, Franziska; Pilz, Julia Beatrice; Pittet, Valérie; Raschle, Nadia; Rentsch, Ronald; Restellini, Sophie; Richterich, Jean-Pierre; Rihs, Sylvia; Ritz, Marc Alain; Roduit, Jocelyn; Rogler, Daniela; Rossel, Jean-Benoît; Sagmeister, Markus; Saner, Gaby; Sauter, Bernhard; Sawatzki, Mikael; Schäppi, Michela; Scharl, Michael; Schelling, Martin; Schibli, Susanne; Schlauri, Hugo; Uebelhart, Sybille Schmid; Schnegg, Jean-François; Schoepfer, Alain; Seibold, Frank; Seirafi, Mariam; Semadeni, Gian-Marco; Semela, David; Senning, Arne; Sidler, Marc; Sokollik, Christiane; Spalinger, Johannes; Spangenberger, Holger; Stadler, Philippe; Steuerwald, Michael; Straumann, Alex; Straumann-Funk, Bigna; Sulz, Michael; Thorens, Joël; Tiedemann, Sarah; Tutuian, Radu; Vavricka, Stephan; Viani, Francesco; Vögtlin, Jürg; Von Känel, Roland; Vonlaufen, Alain; Vouillamoz, Dominique; Vulliamy, Rachel; Wermuth, Jürg; Werner, Helene; Wiesel, Paul; Wiest, Reiner; Wylie, Tina; Zimmermann, Dorothee
Source
BMC Gastroenterology. February 5, 2021, Vol. 21 Issue 1
Subject
Language
English
ISSN
1471-230X
Abstract
Author(s): Martina Ledergerber[sup.1] , Brian M. Lang[sup.2,3] , Henriette Heinrich[sup.1] , Luc Biedermann[sup.1] , Stefan Begré[sup.4] , Jonas Zeitz[sup.1,5] , Niklas Krupka[sup.6] , Andreas Rickenbacher[sup.7] , Matthias Turina[sup.7] , Thomas [...]
Background Abdominal pain is a frequent symptom in patients with inflammatory bowel disease (IBD) including Crohn's disease (CD) and ulcerative colitis (UC). Pain can result from ongoing inflammation or functional disorders imitating irritable bowel syndrome (IBS). Several single-nucleotide polymorphisms (SNPs) have been associated with IBS. However, the impact of IBS genetics on the clinical course of IBD, especially pain levels of patients remains unclear. Methods Data of 857 UC and 1206 CD patients from the Swiss IBD Cohort Study were analysed. We tested the association of the maximum of the abdominal pain item of disease activity indices in UC and CD over the study period with 16 IBS-associated SNPs, using multivariate ANOVA models. Results In UC patients, the SNPs rs1042713 (located on the ADRB2 gene) and rs4663866 (close to the HES6 gene) were associated with higher abdominal pain levels (P = 0.044; P = 0.037, respectively). Abdominal pain was not associated with any markers of patient management in a model adjusted for confounders. In CD patients, higher levels of abdominal pain correlated with the number of physician contacts (P < 10.sup.-15), examinations (P < 10.sup.-12), medical therapies (P = 0.023) and weeks of hospitalisation (P = 0.0013) in a multivariate model. Conclusions We detected an association between maximal abdominal pain in UC patients and two IBS-associated SNPs. Abdominal pain levels had a pronounced impact on diagnostic and therapeutic procedures in CD but not in UC patients. Keywords: Single-nucleotide polymorphisms, Abdominal pain, Inflammatory bowel disease, Ulcerative colitis, Crohn's disease, Irritable bowel syndrome
Background Abdominal pain is a frequent symptom in patients with inflammatory bowel disease (IBD) including Crohn's disease (CD) and ulcerative colitis (UC). Pain can result from ongoing inflammation or functional disorders imitating irritable bowel syndrome (IBS). Several single-nucleotide polymorphisms (SNPs) have been associated with IBS. However, the impact of IBS genetics on the clinical course of IBD, especially pain levels of patients remains unclear. Methods Data of 857 UC and 1206 CD patients from the Swiss IBD Cohort Study were analysed. We tested the association of the maximum of the abdominal pain item of disease activity indices in UC and CD over the study period with 16 IBS-associated SNPs, using multivariate ANOVA models. Results In UC patients, the SNPs rs1042713 (located on the ADRB2 gene) and rs4663866 (close to the HES6 gene) were associated with higher abdominal pain levels (P = 0.044; P = 0.037, respectively). Abdominal pain was not associated with any markers of patient management in a model adjusted for confounders. In CD patients, higher levels of abdominal pain correlated with the number of physician contacts (P < 10.sup.-15), examinations (P < 10.sup.-12), medical therapies (P = 0.023) and weeks of hospitalisation (P = 0.0013) in a multivariate model. Conclusions We detected an association between maximal abdominal pain in UC patients and two IBS-associated SNPs. Abdominal pain levels had a pronounced impact on diagnostic and therapeutic procedures in CD but not in UC patients. Keywords: Single-nucleotide polymorphisms, Abdominal pain, Inflammatory bowel disease, Ulcerative colitis, Crohn's disease, Irritable bowel syndrome