학술논문
Association of Plasminogen Activator Inhibitor 1 (PAI-1) 4G/5G Polymorphism and Susceptibility to SLE in Egyptian Children and Adolescents: A Multicenter Study
Document Type
Academic Journal
Author
Yousef, Aly A.; Mohamed, Faisal Y.; Boraey, Naglaa F.; Akeel, Nagwa E.; Soliman, Attia A.; Waked, Nevin M.; Hashem, Mustafa I.A.; Shehata, Hassan; Fahmy, Dalia S.; Ismael, Ali; Ibrahim, Lamya M.; Ibrahim, Mohamed A.M.; Salem, Hanan F.; Yousry, Sherif M.; Osman, Sherif F.; Fouad, Rania A.; Enan, Eman T.; Attia, Mohammed A.; Afify, Mona R.; Zeidan, Nancy M.S.; Nashat, Mohamed
Source
Journal of Inflammation Research. December 31, 2020, Vol. 13, p1103, 9 p.
Subject
Language
English
ISSN
1178-7031
Abstract
Background: Plasminogen activator inhibitor-1 (PAI-1) is a key molecule residing at the nexus between thrombosis and inflammatory processes. Recently, PAI-1 and its gene expression have emerged as a potential candidate for autoimmune disorders such as SLE. Objective: To investigate whether the PAI-1 4G/5G polymorphism at position -675 could be a genetic marker for susceptibility to childhood-onset SLE and development of lupus nephritis among Egyptian children and adolescents. Methods: Three hundred fifty patients diagnosed with childhood-onset SLE and 350 well-matched healthy controls were included in this multi-center study. All subjects were genotyped for the PAI-1 promoter 4G/5G polymorphism at position -675 using PCR~ restriction fragment length polymorphism (RFLP). Serum PAI-1 levels were measured by ELISA. Results: The PAI-1 (- 675) 4G/4G genotype was more represented in c-SLE patients, as compared to the control group (38% vs 23%; OR =2.7; [95% CI: 1.47-2.9]; P < 0.001). Patients carrying the PAI-1 4G/4G genotype or 4G allele were more likely to develop lupus nephritis (OR: 3.38; [95% CI: 1.9-5.9]; P Conclusion: The PAI-1 4G/5G polymorphism may confer susceptibility to childhood-onset SLE and development of lupus nephritis among Egyptian children and adolescents. Moreover, the PAI-1 4G/4G genotype and 4G allele were associated with higher PAI-1 serum levels and higher disease activity scores. Keywords: plasminogen activator inhibitor-1, PAI-1, gene polymorphism, SLE, children, adolescents
Introduction Childhood-onset systemic lupus erythematosus (cSLE) is a multifaceted autoimmune and inflammatory disease, accounts for about one in every five cases of SLE. (1) cSLE diverse presentation range from mild [...]
Introduction Childhood-onset systemic lupus erythematosus (cSLE) is a multifaceted autoimmune and inflammatory disease, accounts for about one in every five cases of SLE. (1) cSLE diverse presentation range from mild [...]