학술논문
Kirmizi Hucre Dagilim Genisliginin, Inflamatuar Barsak Hastaligi Aktivitesinin Degerlendirmesinde Rolu/Role of Red Cell Distribution Width in Evaluation of Inflammatory Bowel Disease Activity
Orijinal Arastirma / Original Investigation
Orijinal Arastirma / Original Investigation
Document Type
Report
Author
Source
Journal of Academic Research in Medicine. December 2020, Vol. 10 Issue 3, p214, 6 p.
Subject
Language
English
ISSN
2146-6505
Abstract
GIRIS Inflamatuar barsak hastaliginin (IBH), klinik seyri boyunca aktivite ve remisyon dönemleri ile ortaya çikan, gastrointestinal sistemin kronik bir inflamatuar hastaligidir (1). Iki ana fenotip içerir: Crohn hastaligi ve ülseratif [...]
Amaç: Inflamatuar barsak hastaliginin (IBH) aktivite ve remisyon dönemlerinin degerlendirilmesinde, kirmizi hücre dagilim genisliginin (RDW) faydali olup olmadigini belirlemeyi amaçladik. Yöntemler: Bu retrospektif çalismaya 98 ülseratif kolit (UK) ve 34 Crohn hastasindan olusan 132 IBH hastasi dahil edildi. Hastalarin serum C-reaktif protein (CRP) seviyesi, eritrosit sedimentasyon hizi (ESR), lökosit ve trombosit sayilari ve hemoglobin (Hb) konsantrasyonlari, hastalik aktivite ve remisyon dönemlerinde ayri ayri degerlendirildi. UK ve Crohn hastaligi için hastalik aktivitesi sirasiyla Mayo skoru ve Crohn Hastaligi Aktivite Indeksi (CDAI) ile belirlendi. Bulgular: Calismaya dahil edilen hastalarda medyan yas (çeyrekler arasi aralik) 37,5 (29-50), hastalik süresi 29,4[+ or -]44,3 ay olarak saptanmistir. Hastalarin RDW, ESR, CRP degerleri, lökosit ve trombosit sayilari remisyon dönemleri ile karsilastirildiginda, aktif dönemlerinde anlamli olarak yüksekken (p Sonuç: RDW, IBH hastalarinda aktivitenin ve remisyonun bir göstergesi olarak kullanilabilir. RDW, hastalik aktivitesinin takibinde, nüksü öngörmede ve tedavi takibinde kolay ve ucuz bir araç olarak yararli bir ek belirteç olabilir. Anahtar kelimeler: Kirmizi kan hücre dagilim genisligi, inflamatuar barsak hastaligi, aktivite, remisyon Objective: We aimed to determine whether red cell distribution width (RDW is useful in evaluating the activity and remission periods of inflammatory bowel disease (IBD). Methods: One hundred thirty-two IBD patients, consisting of 98 ulcerative colitis (UC) patients and 34 Crohn's patients, were included in this retrospective study. Serum C-reactive protein (CRP) level, erythrocyte sedimentation rate (ESR), leukocyte and platelet counts and hemoglobin (Hb) concentrations were evaluated separately during disease activity and remission periods. Disease activity for UC and Crohn's disease was determined by Mayo score and Crohn's Disease Activity Index (CDAI), respectively. Results: The median age (interquartile range) was 37.5 (29-50) and the duration of the disease was 29.4[+ or -]44.3 months in the patients included in the study. RDW, ESR, CRP values, leukocyte and thrombocyte counts were significantly active periods compared to remission periods (p CRP values and platelet counts were significantly higher during the active periods of patients with UC (36.7%) and Crohn's disease (41.2%) with anemia than those without anemia (p Conclusion: RDW can be used as an indicator of activity and remission in IBD patients. RDW can be a useful additional marker as an easy and inexpensive tool to monitor disease activity, predict relapse, and follow-up treatment. Keywords: Red blood cell distribution width, inflammatory bowel disease, activity, remission
Amaç: Inflamatuar barsak hastaliginin (IBH) aktivite ve remisyon dönemlerinin degerlendirilmesinde, kirmizi hücre dagilim genisliginin (RDW) faydali olup olmadigini belirlemeyi amaçladik. Yöntemler: Bu retrospektif çalismaya 98 ülseratif kolit (UK) ve 34 Crohn hastasindan olusan 132 IBH hastasi dahil edildi. Hastalarin serum C-reaktif protein (CRP) seviyesi, eritrosit sedimentasyon hizi (ESR), lökosit ve trombosit sayilari ve hemoglobin (Hb) konsantrasyonlari, hastalik aktivite ve remisyon dönemlerinde ayri ayri degerlendirildi. UK ve Crohn hastaligi için hastalik aktivitesi sirasiyla Mayo skoru ve Crohn Hastaligi Aktivite Indeksi (CDAI) ile belirlendi. Bulgular: Calismaya dahil edilen hastalarda medyan yas (çeyrekler arasi aralik) 37,5 (29-50), hastalik süresi 29,4[+ or -]44,3 ay olarak saptanmistir. Hastalarin RDW, ESR, CRP degerleri, lökosit ve trombosit sayilari remisyon dönemleri ile karsilastirildiginda, aktif dönemlerinde anlamli olarak yüksekken (p Sonuç: RDW, IBH hastalarinda aktivitenin ve remisyonun bir göstergesi olarak kullanilabilir. RDW, hastalik aktivitesinin takibinde, nüksü öngörmede ve tedavi takibinde kolay ve ucuz bir araç olarak yararli bir ek belirteç olabilir. Anahtar kelimeler: Kirmizi kan hücre dagilim genisligi, inflamatuar barsak hastaligi, aktivite, remisyon Objective: We aimed to determine whether red cell distribution width (RDW is useful in evaluating the activity and remission periods of inflammatory bowel disease (IBD). Methods: One hundred thirty-two IBD patients, consisting of 98 ulcerative colitis (UC) patients and 34 Crohn's patients, were included in this retrospective study. Serum C-reactive protein (CRP) level, erythrocyte sedimentation rate (ESR), leukocyte and platelet counts and hemoglobin (Hb) concentrations were evaluated separately during disease activity and remission periods. Disease activity for UC and Crohn's disease was determined by Mayo score and Crohn's Disease Activity Index (CDAI), respectively. Results: The median age (interquartile range) was 37.5 (29-50) and the duration of the disease was 29.4[+ or -]44.3 months in the patients included in the study. RDW, ESR, CRP values, leukocyte and thrombocyte counts were significantly active periods compared to remission periods (p CRP values and platelet counts were significantly higher during the active periods of patients with UC (36.7%) and Crohn's disease (41.2%) with anemia than those without anemia (p Conclusion: RDW can be used as an indicator of activity and remission in IBD patients. RDW can be a useful additional marker as an easy and inexpensive tool to monitor disease activity, predict relapse, and follow-up treatment. Keywords: Red blood cell distribution width, inflammatory bowel disease, activity, remission