학술논문
Quantitative dynamic contrast-enhanced MR imaging can be used to predict the pathologic stages of oral tongue squamous cell carcinoma
Document Type
Clinical report
Author
Source
BMC Medical Imaging. October 16, 2020, Vol. 20 Issue 1
Subject
Language
English
ISSN
1471-2342
Abstract
Author(s): Na Guo[sup.1,3], Weike Zeng[sup.1], Hong Deng[sup.1], Huijun Hu[sup.1], Ziliang Cheng[sup.1,2], Zehong Yang[sup.1,2], Shuqi Jiang[sup.1], Xiaohui Duan[sup.1,2] and Jun Shen[sup.1,2] Background Oral tongue squamous cell carcinoma (OTSCC) is the most [...]
Background To investigate whether quantitative dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) pharmacokinetic parameters can be used to predict the pathologic stages of oral tongue squamous cell carcinoma (OTSCC). Methods For this prospective study, DCE-MRI was performed in participants with OTSCC from May 2016 to June 2017. The pharmacokinetic parameters, including K.sup.trans, K.sub.ep, V.sub.e, and V.sub.p, were derived from DCE-MRI by utilizing a two-compartment extended Tofts model and a three-dimensional volume of interest. The postoperative pathologic stage was determined in each patient based on the 8th AJCC cancer staging manual. The quantitative DCE-MRI parameters were compared between stage I-II and stage III-IV lesions. Logistic regression analysis was used to determine independent predictors of tumor stages, followed by receiver operating characteristic (ROC) analysis to evaluate the predictive performance. Results The mean K.sup.trans, K.sub.ep and V.sub.p values were significantly lower in stage III-IV lesions compared with stage I-II lesions (p = 0.013, 0.005 and 0.011, respectively). K.sub.ep was an independent predictor for the advanced stages as determined by univariate and multivariate logistic analysis. ROC analysis showed that K.sub.ep had the highest predictive capability, with a sensitivity of 64.3%, a specificity of 82.6%, a positive predictive value of 81.8%, a negative predictive value of 65.5%, and an accuracy of 72.5%. Conclusion The quantitative DCE-MRI parameter K.sub.ep can be used as a biomarker for predicting pathologic stages of OTSCC. Keywords: Tongue neoplasms, Squamous cell carcinoma, Magnetic resonance imaging, Contrast media, Neoplasm staging
Background To investigate whether quantitative dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) pharmacokinetic parameters can be used to predict the pathologic stages of oral tongue squamous cell carcinoma (OTSCC). Methods For this prospective study, DCE-MRI was performed in participants with OTSCC from May 2016 to June 2017. The pharmacokinetic parameters, including K.sup.trans, K.sub.ep, V.sub.e, and V.sub.p, were derived from DCE-MRI by utilizing a two-compartment extended Tofts model and a three-dimensional volume of interest. The postoperative pathologic stage was determined in each patient based on the 8th AJCC cancer staging manual. The quantitative DCE-MRI parameters were compared between stage I-II and stage III-IV lesions. Logistic regression analysis was used to determine independent predictors of tumor stages, followed by receiver operating characteristic (ROC) analysis to evaluate the predictive performance. Results The mean K.sup.trans, K.sub.ep and V.sub.p values were significantly lower in stage III-IV lesions compared with stage I-II lesions (p = 0.013, 0.005 and 0.011, respectively). K.sub.ep was an independent predictor for the advanced stages as determined by univariate and multivariate logistic analysis. ROC analysis showed that K.sub.ep had the highest predictive capability, with a sensitivity of 64.3%, a specificity of 82.6%, a positive predictive value of 81.8%, a negative predictive value of 65.5%, and an accuracy of 72.5%. Conclusion The quantitative DCE-MRI parameter K.sub.ep can be used as a biomarker for predicting pathologic stages of OTSCC. Keywords: Tongue neoplasms, Squamous cell carcinoma, Magnetic resonance imaging, Contrast media, Neoplasm staging