학술논문
Plasma A[beta] and neurofilament light chain are associated with cognitive and physical function decline in non-dementia older adults
Document Type
Clinical report
Author
He, Lingxiao; de Souto Barreto, Philipe; Aggarwal, Geetika; Nguyen, Andrew D.; Morley, John E.; Li, Yan; Bateman, Randall J.; Vellas, Bruno; Vellas, Bruno; Guyonnet, Sophie; Carrié, Isabelle; Brigitte, Lauréane; Faisant, Catherine; Lala, Françoise; Delrieu, Julien; Villars, Hélène; Combrouze, Emeline; Badufle, Carole; Zueras, Audrey; Andrieu, Sandrine; Cantet, Christelle; Morin, Christophe; Van Kan, Gabor Abellan; Dupuy, Charlotte; Rolland, Yves; Caillaud, Céline; Ousset, Pierre-Jean; Lala, Françoise; Willis, Sherry; Belleville, Sylvie; Gilbert, Brigitte; Dartigues, Jean-François; Marcet, Isabelle; Delva, Fleur; Foubert, Alexandra; Cerda, Sandrine; Costes, Corinne; Rouaud, Olivier; Manckoundia, Patrick; Quipourt, Valérie; Marilier, Sophie; Franon, Evelyne; Bories, Lawrence; Pader, Marie-Laure; Basset, Marie-France; Lapoujade, Bruno; Faure, Valérie; Tong, Michael Li Yung; Malick-Loiseau, Christine; Cazaban-Campistron, Evelyne; Desclaux, Françoise; Blatge, Colette; Dantoine, Thierry; Laubarie-Mouret, Cécile; Saulnier, Isabelle; Clément, Jean-Pierre; Picat, Marie-Agnès; Bernard-Bourzeix, Laurence; Willebois, Stéphanie; Désormais, Iléana; Cardinaud, Noëlle; Bonnefoy, Marc; Livet, Pierre; Rebaudet, Pascale; Gédéon, Claire; Burdet, Catherine; Terracol, Flavien; Pesce, Alain; Roth, Stéphanie; Chaillou, Sylvie; Louchart, Sandrine; Sudres, Kristelle; Lebrun, Nicolas; Barro-Belaygues, Nadège; Touchon, Jacques; Bennys, Karim; Gabelle, Audrey; Romano, Aurélia; Touati, Lynda; Marelli, Cécilia; Pays, Cécile; Robert, Philippe; Le Duff, Franck; Gervais, Claire; Gonfrier, Sébastien; Gasnier, Yannick; Bordes, Serge; Begorre, Danièle; Carpuat, Christian; Khales, Khaled; Lefebvre, Jean-François; El Idrissi, Samira Misbah; Skolil, Pierre; Salles, Jean-Pierre; Dufouil, Carole; Lehéricy, Stéphane; Chupin, Marie; Mangin, Jean-François; Bouhayia, Ali; Allard, Michèle; Ricolfi, Frédéric; Dubois, Dominique; Martel, Marie Paule Bonceour; Cotton, François; Bonafé, Alain; Chanalet, Stéphane; Hugon, Françoise; Bonneville, Fabrice; Cognard, Christophe; Chollet, François; Payoux, Pierre; Voisin, Thierry; Delrieu, Julien; Peiffer, Sophie; Hitzel, Anne; Allard, Michèle; Zanca, Michel; Monteil, Jacques; Darcourt, Jacques; Molinier, Laurent; Derumeaux, Hélène; Costa, Nadège; Perret, Bertrand; Vinel, Claire; Caspar-Bauguil, Sylvie; Olivier-Abbal, Pascale; Andrieu, Sandrine; Cantet, Christelle; Coley, Nicola
Source
Alzheimer's Research & Therapy. October 8, 2020, Vol. 12 Issue 1
Subject
Language
English
ISSN
1758-9193
Abstract
Background Cognition is closely associated with physical function. Although high brain amyloid-[beta] (A[beta]) deposition and neurofilament light chain (NfL) are associated with cognitive and gait speed decline, relationships of combined plasma A[beta] and NfL profiles with cognitive and physical functions in older adults remain unknown. The research aim of this study was to investigate the prospective associations of combined plasma A[beta] and NfL profiles with cognitive and physical functions in older adults. Methods Participants (n = 452, aged 76 [+ or -] 5 years) who had both plasma A[beta] and NfL data collected from the Multidomain Alzheimer's Preventive Trial (MAPT, May 2008 to April 2016) were included in the current study. These participants were from four MAPT groups (multidomain interventions [physical activity and nutritional counselling, and cognitive training], omega-3 supplementation, multidomain plus omega-3 supplementation and control group) and had received a 3-year intervention, followed by a 2-year observational follow-up. Cognitive function was evaluated as Mini-Mental State Examination and composite cognitive score (CCS, a mean Z-score combining four cognitive tests). Physical function was evaluated as gait speed (4-m usual-pace walk test) and chair-stand time (5-time maximal chair-stand test). Cognitive and physical function data measured at the time of and after blood A[beta] and NfL tests were used for analysis. Participants with plasma A[beta].sub.42/A[beta].sub.40 ratios lower than 0.107 and NfL levels greater than 93.04 pg/ml were classified as A[beta]+ and NfL+. Multivariable regressions and mixed-effects linear models were used for the analysis. Results At the cross-sectional level, no significant association was found between A[beta]+NfL+ and cognitive or physical function after controlling for age, sex, body mass index, education level and MAPT group. Evaluating longitudinal changes, participants with A[beta]+NfL+ had greater annual declines in the CCS ([beta] = - 0.11, 95%CI [- 0.17, - 0.05]) and gait speed ([beta] = - 0.03, 95%CI [- 0.05, - 0.005]). After adjusting for APOE É4 genotype, A[beta]+NfL+ was associated with a greater decline only in the CCS ([beta] = - 0.09, 95%CI [- 0.15, - 0.02]). Conclusions Combined low plasma A[beta].sub.42/A[beta].sub.40 ratio and high plasma NfL level was associated with greater declines in cognition and gait speed over time, providing further evidence of the links between cognitive and physical function. Trial registration www.clinicaltrials.gov [NCT00672685]. Keywords: Amyloid-[beta], Neurofilament light chain, Cognitive function, Physical function
Author(s): Lingxiao He[sup.1], Philipe de Souto Barreto[sup.1,2], Geetika Aggarwal[sup.3,4], Andrew D. Nguyen[sup.3,4], John E. Morley[sup.3], Yan Li[sup.5], Randall J. Bateman[sup.5], Bruno Vellas[sup.1,2], Bruno Vellas, Sophie Guyonnet, Isabelle Carrié, Lauréane Brigitte, [...]
Author(s): Lingxiao He[sup.1], Philipe de Souto Barreto[sup.1,2], Geetika Aggarwal[sup.3,4], Andrew D. Nguyen[sup.3,4], John E. Morley[sup.3], Yan Li[sup.5], Randall J. Bateman[sup.5], Bruno Vellas[sup.1,2], Bruno Vellas, Sophie Guyonnet, Isabelle Carrié, Lauréane Brigitte, [...]