부산대학교 도서관

Background/Objective: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the progressive loss of central and peripheral motor neurons. Some studies have found discordant data in the presence of sleep apnea in ALS patients. An obstructive component also occurs with upper airways hypotonia and muscle weakness that may result in an excessive reduction of airway lumen, leading to obstructive sleep apnea (OSA). The aim of this study was to assess the role of obstructive apneic events at disease onset in the ALS prognosis. Methods: A longitudinal retrospective study was conducted on 42 clinically diagnosed ALS patients. The study population was divided into 2 groups according to their obstructive apnea/hypopnea index (AHIo): group 1 consisted of 20 patients with an AHIo [GreaterEqual]5 and group 2 consisted of 22 patients with an AHIo Keywords: Amyotrophic lateral sclerosis, Obstructive sleep apnea, Central sleep apnea, Sniff nasal inspiratory pressure, Forced vital capacity, Onset, Prognosis, Sleep-disordered breathing
Author(s): Vitaliano Nicola Quaranta; Pierluigi Carratø; Mario Francesco Damiani; Silvano Dragonieri; Alberto Capozzolo; Anna Cassano; Onofrio Resta Introduction Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the progressive [...]