학술논문
Shelterin Complex at Telomeres: Implications in Ageing
Document Type
Academic Journal
Author
Source
Clinical Interventions in Aging. June 30, 2020, Vol. 15, p827, 12 p.
Subject
Language
English
ISSN
1178-1998
Abstract
Introduction Telomeres are nucleoprotein structures at the end of eukaryotic chromosomes, which consist of DNA repeating sequences (TTAGGG) and individual proteins. These structures maintain genome integrity by capping the chromosome [...]
Different factors influence the development and control of ageing. It is well known that progressive telomere shorting is one of the molecular mechanisms underlying ageing. The shelterin complex consists of six telomere-specific proteins which are involved in the protection of chromosome ends. More particularly, this vital complex protects the telomeres from degradation, prevents from activation of unwanted repair systems, regulates the activity of telomerase, and has a crucial role in cellular senescent and ageing-related pathologies. This review explores the organization and function of telomeric DNA along with the mechanism of telomeres during ageing, followed by a discussion of the critical role of shelterin components and their changes during ageing. Keywords: ageing, sheltering complex, telomeres
Different factors influence the development and control of ageing. It is well known that progressive telomere shorting is one of the molecular mechanisms underlying ageing. The shelterin complex consists of six telomere-specific proteins which are involved in the protection of chromosome ends. More particularly, this vital complex protects the telomeres from degradation, prevents from activation of unwanted repair systems, regulates the activity of telomerase, and has a crucial role in cellular senescent and ageing-related pathologies. This review explores the organization and function of telomeric DNA along with the mechanism of telomeres during ageing, followed by a discussion of the critical role of shelterin components and their changes during ageing. Keywords: ageing, sheltering complex, telomeres