학술논문
Protective Effects of Curcumin and its Nano-Phytosome on Carrageenan-Induced Inflammation in Mice Model: Behavioral and Biochemical Responses
ORIGINAL RESEARCH
ORIGINAL RESEARCH
Document Type
Academic Journal
Author
Source
Journal of Inflammation Research. January 2020, Vol. 13, p45, 7 p.
Subject
Language
English
ISSN
1178-7031
Abstract
Introduction Inflammation is a defensive response that is marked with increased pro-inflammatory cytokines. (1) Some compounds are extensively used for inducing inflammation. Carrageenan, a sulfated polysaccharide, is broadly applied as [...]
Background and purpose: Natural compounds are used for prevention of inflammation. Curcumin has antioxidant and anti-inflammatory properties, and loading it into nano-phytosomes may improve its efficiency. The present study investigates the effects of curcumin and its nano-phytosome on behavioral and biochemical responses in carrageenan-induced inflammation in the mice model. Methods: The mice were divided into six groups and received oral administration of curcumin or its nano-phytosome at a dose of 15 mg/kg for seven days before the administration of carrageenan. Acute inflammation in the mice was induced by administration of carrageenan (1%) into the subplantar region of the left paw. Antioxidant activity and behavioral responses were then evaluated. Results: The results showed that the serum concentrations of antioxidant enzymes were significantly higher in the sal+sal group compared to the cara+sal group (P Conclusion: It can be stated that the nano-phytosome of curcumin could improve antioxidant and behavioral responses in inflamed mice. Keywords: antioxidant activity, inflammation, mice model, nano-phytosome
Background and purpose: Natural compounds are used for prevention of inflammation. Curcumin has antioxidant and anti-inflammatory properties, and loading it into nano-phytosomes may improve its efficiency. The present study investigates the effects of curcumin and its nano-phytosome on behavioral and biochemical responses in carrageenan-induced inflammation in the mice model. Methods: The mice were divided into six groups and received oral administration of curcumin or its nano-phytosome at a dose of 15 mg/kg for seven days before the administration of carrageenan. Acute inflammation in the mice was induced by administration of carrageenan (1%) into the subplantar region of the left paw. Antioxidant activity and behavioral responses were then evaluated. Results: The results showed that the serum concentrations of antioxidant enzymes were significantly higher in the sal+sal group compared to the cara+sal group (P Conclusion: It can be stated that the nano-phytosome of curcumin could improve antioxidant and behavioral responses in inflamed mice. Keywords: antioxidant activity, inflammation, mice model, nano-phytosome