학술논문
TNF-[alpha] (-308) Gene Polymorphism and Type 2 Diabetes Mellitus in Ethiopian Diabetes Patients
ORIGINAL RESEARCH
ORIGINAL RESEARCH
Document Type
Academic Journal
Author
Source
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. December 2019, p2453, 7 p.
Subject
Language
English
ISSN
1178-7007
Abstract
Background Diabetes Mellitus (DM) is a chronic disease characterized by impaired metabolism of glucose due to defects in insulin secretion or action. (1,2) Globally, the number of adults living with [...]
Background: Type 2 diabetes mellitus (T2DM) is a metabolic disorder resulting from insulin insufficiency or function. Predisposing factors for T2DM are mainly genetic and environmental. Genetic polymorphism of cytokines like tumor necrosis factor-alpha (TNF-[alpha]) is suggestive of interference with insulin-sensitive glucose uptake and induces insulin resistance that ultimately could lead to T2DM. In this study, we assessed the effect of TNF-[alpha] (-308) G/A gene polymorphism and its association with the development of T2DM in an Ethiopian population. Methods: An institutional-based cross-sectional study was conducted on study subjects with T2DM and non-diabetic healthy controls. DNA was extracted and genotyping was carried out by using amplification refractory mutation system polymerase chain reaction. A genetic-polymorphism on TNF-[alpha] (-308) G/A with T2DM was evaluated by logistic regression and Student's t-test. A P-value Conclusion: TNF-[alpha] (-308) genetic polymorphism may be implicated in the genetic susceptibility for, as well as the development of T2DM and lipid metabolism in the Ethiopian population. Therefore, a large-scale study and early screening of TNF-[alpha] (-308) genetic polymorphism may help in early management and control of diabetes and related outcomes. Keywords: TNF-[alpha], T2DM, North West Ethiopia
Background: Type 2 diabetes mellitus (T2DM) is a metabolic disorder resulting from insulin insufficiency or function. Predisposing factors for T2DM are mainly genetic and environmental. Genetic polymorphism of cytokines like tumor necrosis factor-alpha (TNF-[alpha]) is suggestive of interference with insulin-sensitive glucose uptake and induces insulin resistance that ultimately could lead to T2DM. In this study, we assessed the effect of TNF-[alpha] (-308) G/A gene polymorphism and its association with the development of T2DM in an Ethiopian population. Methods: An institutional-based cross-sectional study was conducted on study subjects with T2DM and non-diabetic healthy controls. DNA was extracted and genotyping was carried out by using amplification refractory mutation system polymerase chain reaction. A genetic-polymorphism on TNF-[alpha] (-308) G/A with T2DM was evaluated by logistic regression and Student's t-test. A P-value Conclusion: TNF-[alpha] (-308) genetic polymorphism may be implicated in the genetic susceptibility for, as well as the development of T2DM and lipid metabolism in the Ethiopian population. Therefore, a large-scale study and early screening of TNF-[alpha] (-308) genetic polymorphism may help in early management and control of diabetes and related outcomes. Keywords: TNF-[alpha], T2DM, North West Ethiopia