학술논문
HIV prevalence in suspected Ebola cases during the 2014-2016 Ebola epidemic in Sierra Leone
Document Type
Report
Author
Liu, William J.; Hu, Hai-Yang; Su, Qiu-Dong; Zhang, Zhe; Liu, Yang; Sun, Yu-Lan; Yang, Xian-Da; Sun, Da-Peng; Cai, Shao-Jian; Yang, Xiu-Xu; Kamara, Idrissa; Kamara, Abdul; Lebby, Matt; Kargbo, Brima; Ongpin, Patricia; Dong, Xiao-Ping; Shu, Yue-Long; Xu, Wen-Bo; Wu, Gui-Zhen; Gboun, Michael; Gao, George F.
Source
Infectious Diseases of Poverty. March 4, 2019, Vol. 8 Issue 1
Subject
Language
English
ISSN
2049-9957
Abstract
Author(s): William J. Liu[sup.1,12] , Hai-Yang Hu[sup.2,12] , Qiu-Dong Su[sup.1,12] , Zhe Zhang[sup.3,12] , Yang Liu[sup.1,12] , Yu-Lan Sun[sup.4,12] , Xian-Da Yang[sup.5,12] , Da-Peng Sun[sup.6,12] , Shao-Jian Cai[sup.7,12] , Xiu-Xu [...]
Background The 2014-2016 Ebola virus epidemic in West Africa was the largest outbreak of Ebola virus disease (EVD) in history. Clarifying the influence of other prevalent diseases such as human immunodeficiency virus infection and acquired immune deficiency syndrome (HIV/AIDS) will help improve treatment and supportive care of patients with EVD. Case presentation We examined HIV and hepatitis C virus (HCV) antibody prevalence among suspected EVD cases from the Sierra Leone-China Friendship Biological Safety Laboratory during the epidemic in Sierra Leone. HIV and HCV antibodies were tested in 678 EVD-negative samples by enzyme-linked immunosorbent assay. A high HIV prevalence (17.6%) and low HCV prevalence (0.22%) were observed among the suspected cases. Notably, we found decreased HIV positive rates among the suspected cases over the course of the epidemic. This suggests a potentially beneficial effect of an improved public health system after assistance from the World Health Organization and other international aid organizations. Conclusions This EVD epidemic had a considerable impact on the public health system and influenced the prevalence of HIV found among suspected cases in Sierra Leone, but also provided an opportunity to establish a better surveillance network for infectious diseases. Keywords: HIV, HCV, Ebola, Prevalence, Sierra Leone
Background The 2014-2016 Ebola virus epidemic in West Africa was the largest outbreak of Ebola virus disease (EVD) in history. Clarifying the influence of other prevalent diseases such as human immunodeficiency virus infection and acquired immune deficiency syndrome (HIV/AIDS) will help improve treatment and supportive care of patients with EVD. Case presentation We examined HIV and hepatitis C virus (HCV) antibody prevalence among suspected EVD cases from the Sierra Leone-China Friendship Biological Safety Laboratory during the epidemic in Sierra Leone. HIV and HCV antibodies were tested in 678 EVD-negative samples by enzyme-linked immunosorbent assay. A high HIV prevalence (17.6%) and low HCV prevalence (0.22%) were observed among the suspected cases. Notably, we found decreased HIV positive rates among the suspected cases over the course of the epidemic. This suggests a potentially beneficial effect of an improved public health system after assistance from the World Health Organization and other international aid organizations. Conclusions This EVD epidemic had a considerable impact on the public health system and influenced the prevalence of HIV found among suspected cases in Sierra Leone, but also provided an opportunity to establish a better surveillance network for infectious diseases. Keywords: HIV, HCV, Ebola, Prevalence, Sierra Leone