학술논문
INCIDENTAL PROSTATE CANCER IN PATIENTS TREATED FOR BENIGN PROSTATE HYPERPLASIA IN THE PERIOD OF 21 YEARS/INCIDENTALNI KARCINOM PROSTATE U PACIJENATA LIJECENIH ZBOG BENIGNE HIPERPLAZIJE PROSTATE U PERIODU OD 21 GODINE
Original Scientific Paper
Original Scientific Paper
Document Type
Clinical report
Author
Source
Acta Clinica Croatica. March 15, 2018, Vol. 57 Issue S1, p71, 6 p.
Subject
Language
English
ISSN
0353-9466
Abstract
IntroductionIncidental prostate cancer is detected in histopathologic samples of men undergoing transurethral prostate resection (TURP) or transvesical adenomectomy for bladder outlet obstruction symptoms and related conditions (such as bladder stones, [...]
The aim of this study was to determine the incidence of incidental prostate cancer and its clinical significance among patients who underwent transurethral prostate resection or transvesical adenomectomy for benign prostate hyperplasia at the Department of Urology in Sestre milosrdnice University Hospital Center from January 1997 to December 2017. A total of 277/4,372 (6.34%) patients from our cohort were diagnosed with incidental prostate cancer (mean age 74.5 years). Due to incomplete data, 12 patents were excluded from further analysis. 44.91% (119/265 patents) of our cohort were stage T1a and 55.09% (146/265) were stage T1b. Clinically significant prostate cancer was found in 168/265 patients (63.40%). When divided into two groups, Gleason score [less than or equal to]6 (mean age 73.58 years) and Gleason score [greater than or equal to]7 (mean age 75.77 years), the results showed that Gleason score [greater than or equal to]7 patients were significantly older (p=0.0104) and that the tumor extent among patients in this group (mean = 34.58%) was higher than that in Gleason score [less than or equal to]6 group (mean = 11.11%) (p=0.0169). More than a half of patients in our cohort had T1b stage prostate cancer. We found that 63.4% of carcinomas were clinically significant, with 52/265 (19,62%) patients affected by ISUP grade 4 and 5 cancers. Based on our research, we cannot give any recommendations regarding incidental prostate cancer treatment due to lacking preoperative (PSA, DRE) and follow-up data.Key words: Benign prostate hyperplasia; BPH; Incidental prostate cancer; TURPCilj ovog rada bio je utvrditi ucestalost incidentalnog karcinoma prostate i klinicki znacaj istog u pacijenata podvrgnutih transuretralnoj resekciji prostate i transvezikalnoj prostatektomiji zbog benigne prostaticne hiperplazije na Klinici za urologiju KBC-a 'Sestre milosrdnice' od sijecnja 1997. do prosinca 2017. godine. Incidentalni karcinom prostate pronaden je kod 277/4,372 (6,34%) pacijenata iz nase studije (prosjecna dob 74,5 godina). Zbog neadekvatnih podataka, 12 pacijentata iskljuceno je iz daljnje analize. 44,91% (119/265 pacijenata) nalazilo se u T1a stadiju, a 55,09% (145/265) u T1b stadiju bolesti. Klinicki znacajan karcinom pronaden je kod 168/246 pacijenata (60,40%). Kada se pacijenti podijele u dvije skupine, Gleason zbroj [less than or equal to]6 (srednja dob 73,58 godina) i Gleason zbroj [greater than or equal to]7 (srednja dob 75,77 godina), rezultati pokazuju da su pacijenti s karcinomom prostate Gleason zbroja [greater than or equal to]7 statisticki znacajno stariji (p=0,0104) te da karcinom zahvaca veci dio pregledanog tkiva (prosjek= 34,58%) nego u bolesnika s karcinomom Gleason zbroja [less than or equal to]6 (prosjek= 11,11%) (p=0,0169). U nasoj studiji, vise od polovice pacijenata s dijagnosticiranim karcinomom imalo je T1b stadij karcinoma prostate, 63,4% pacijenata imalo je klinicki znacajan karcinom, od cega je 52/265 (19,62%) pacijenata bolovalo od karcinoma ISUP stadija 4 i 5. Na temelju ovog istrazivanja ne mozemo dati preporuke o lijecenju novodijagnosticiranog incidentalnog karcinoma prostate zbog insuficijentnih preoperativnih parametara (PSA, digitorektalni pregled) te nedostatnih podataka o postoperativnom pracenju tih pacijenata.Kljucne rijeci: Benigna hiperplazija prostate; BPH; Incidentalni karcinom prostate; TURP
The aim of this study was to determine the incidence of incidental prostate cancer and its clinical significance among patients who underwent transurethral prostate resection or transvesical adenomectomy for benign prostate hyperplasia at the Department of Urology in Sestre milosrdnice University Hospital Center from January 1997 to December 2017. A total of 277/4,372 (6.34%) patients from our cohort were diagnosed with incidental prostate cancer (mean age 74.5 years). Due to incomplete data, 12 patents were excluded from further analysis. 44.91% (119/265 patents) of our cohort were stage T1a and 55.09% (146/265) were stage T1b. Clinically significant prostate cancer was found in 168/265 patients (63.40%). When divided into two groups, Gleason score [less than or equal to]6 (mean age 73.58 years) and Gleason score [greater than or equal to]7 (mean age 75.77 years), the results showed that Gleason score [greater than or equal to]7 patients were significantly older (p=0.0104) and that the tumor extent among patients in this group (mean = 34.58%) was higher than that in Gleason score [less than or equal to]6 group (mean = 11.11%) (p=0.0169). More than a half of patients in our cohort had T1b stage prostate cancer. We found that 63.4% of carcinomas were clinically significant, with 52/265 (19,62%) patients affected by ISUP grade 4 and 5 cancers. Based on our research, we cannot give any recommendations regarding incidental prostate cancer treatment due to lacking preoperative (PSA, DRE) and follow-up data.Key words: Benign prostate hyperplasia; BPH; Incidental prostate cancer; TURPCilj ovog rada bio je utvrditi ucestalost incidentalnog karcinoma prostate i klinicki znacaj istog u pacijenata podvrgnutih transuretralnoj resekciji prostate i transvezikalnoj prostatektomiji zbog benigne prostaticne hiperplazije na Klinici za urologiju KBC-a 'Sestre milosrdnice' od sijecnja 1997. do prosinca 2017. godine. Incidentalni karcinom prostate pronaden je kod 277/4,372 (6,34%) pacijenata iz nase studije (prosjecna dob 74,5 godina). Zbog neadekvatnih podataka, 12 pacijentata iskljuceno je iz daljnje analize. 44,91% (119/265 pacijenata) nalazilo se u T1a stadiju, a 55,09% (145/265) u T1b stadiju bolesti. Klinicki znacajan karcinom pronaden je kod 168/246 pacijenata (60,40%). Kada se pacijenti podijele u dvije skupine, Gleason zbroj [less than or equal to]6 (srednja dob 73,58 godina) i Gleason zbroj [greater than or equal to]7 (srednja dob 75,77 godina), rezultati pokazuju da su pacijenti s karcinomom prostate Gleason zbroja [greater than or equal to]7 statisticki znacajno stariji (p=0,0104) te da karcinom zahvaca veci dio pregledanog tkiva (prosjek= 34,58%) nego u bolesnika s karcinomom Gleason zbroja [less than or equal to]6 (prosjek= 11,11%) (p=0,0169). U nasoj studiji, vise od polovice pacijenata s dijagnosticiranim karcinomom imalo je T1b stadij karcinoma prostate, 63,4% pacijenata imalo je klinicki znacajan karcinom, od cega je 52/265 (19,62%) pacijenata bolovalo od karcinoma ISUP stadija 4 i 5. Na temelju ovog istrazivanja ne mozemo dati preporuke o lijecenju novodijagnosticiranog incidentalnog karcinoma prostate zbog insuficijentnih preoperativnih parametara (PSA, digitorektalni pregled) te nedostatnih podataka o postoperativnom pracenju tih pacijenata.Kljucne rijeci: Benigna hiperplazija prostate; BPH; Incidentalni karcinom prostate; TURP