학술논문
Use of synthetic adrenocorticotropic hormone in patients with IgA nephropathy
immunoglobulin A
immunoglobulin A
Document Type
Report
Source
BMC Nephrology. May 23, 2018, Vol. 19 Issue 1
Subject
Language
English
ISSN
1471-2369
Abstract
Author(s): Bhanu Prasad[sup.1] , Shelley Giebel[sup.2] , Michelle C. E. McCarron[sup.3] and Nelson Leung[sup.4] Background Immunoglobulin A (IgA) nephropathy is the most common primary glomerulopathy in the developed world [1, [...]
Background Synthetic adrenocorticotropic hormone (ACTH) has been demonstrated to be effective in patients with membranous nephropathy, minimal change disease and some histological subtypes of focal segmental glomerulosclerosis. Its clinical impact in patients with IgA nephropathy is currently unclear. Case presentation In this report, we describe the clinical use of ACTH in patients with IgA nephropathy. Three female patients (24-44 years) with overt proteinuria received intramuscular (IM) ACTH for varying time periods (8-14 months). Pre-treatment urine protein varied from 2.9 g/d to 4.3 g/d. Conclusions There was complete remission in one patient on ACTH monotherapy and in the other two when prescribed as a steroid-sparing agent in combination with cyclophosphamide. All three had resolution in proteinuria to less than 1 g/d and maintained their GFR to baseline values. There were no reported side effects at a once a week dose. This study illustrates that ACTH is an effective agent that is well tolerated with minimal side effects and can be used as an alternative to prednisone in patients with IgA nephropathy. Keywords: IgA nephropathy, Adrenocorticotropic hormone, Proteinuria, Prednisone
Background Synthetic adrenocorticotropic hormone (ACTH) has been demonstrated to be effective in patients with membranous nephropathy, minimal change disease and some histological subtypes of focal segmental glomerulosclerosis. Its clinical impact in patients with IgA nephropathy is currently unclear. Case presentation In this report, we describe the clinical use of ACTH in patients with IgA nephropathy. Three female patients (24-44 years) with overt proteinuria received intramuscular (IM) ACTH for varying time periods (8-14 months). Pre-treatment urine protein varied from 2.9 g/d to 4.3 g/d. Conclusions There was complete remission in one patient on ACTH monotherapy and in the other two when prescribed as a steroid-sparing agent in combination with cyclophosphamide. All three had resolution in proteinuria to less than 1 g/d and maintained their GFR to baseline values. There were no reported side effects at a once a week dose. This study illustrates that ACTH is an effective agent that is well tolerated with minimal side effects and can be used as an alternative to prednisone in patients with IgA nephropathy. Keywords: IgA nephropathy, Adrenocorticotropic hormone, Proteinuria, Prednisone