부산대학교 도서관

Background Chronic inflammation is related to both obesity and diabetes. Our aim was to investigate to what extent this inflammation contributes to the association between obesity and diabetes. Methods Using a case-cohort design, we followed 567 middle-aged individuals who developed diabetes and 554 who did not over 9 years within the ARIC Study. Weighted Cox proportional hazards analyses permitted statistical inference to the entire cohort. Results Obese individuals (BMI[greater than or equai to]30 kg/m.sup.2), compared to those with BMI Conclusions The marked decrease in the obesity-diabetes association after taking into account inflammation markers and adipokines indicates their major role in the pathways leading to adult onset of diabetes in obese individuals. Keywords: Diabetes, Obesity, Inflammation, Adipokines, Humans, Epidemiologic studies
Author(s): Vivian C Luft[sup.1] , Maria I Schmidt[sup.1,2] , James S Pankow[sup.3] , David Couper[sup.4] , Christie M Ballantyne[sup.5] , J Hunter Young[sup.6] and Bruce B Duncan[sup.1,2] Background Diabetes is [...]