부산대학교 도서관

To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1016/j.ajo.2017.05.024 Byline: Wenying Fan (a,b,c,*), Kang Wang (d,*), Khalil Ghasemi Falavarjani (a,b), Min Sagong (e), Akihito Uji (a,b), Michael Ip (a,b), Charles C. Wykoff (f,g), David M. Brown (f,g), Jano van Hemert (h), SriniVas R. Sadda [ssadda@doheny.org] (a,b,*) Purpose To explore the distribution of nonperfusion area (NPA) in eyes with diabetic macular edema (DME) and its relationship with the severity of DME. Design Prospective, observational case series. Methods Forty eyes of 29 patients with treatment-naAaAaAeA ve DME who participat in the DAVE study (NCT01552408) were included. Ultra-widefield fluorescein angiography images were sent to the Doheny Image Reading Center, where they were montaged and corrected using stereographic projection to adjust for peripheral distortion. Two experienced, independent/masked certified graders manually segmented the NPA and the total visible retinal area (TRA), and computed the NPA and TRA in square millimeters (mm.sup.2). The ischemic index (ISI) was calculated. The distributions of NPA and ISI within different retinal zones were correlated with the severity of DME. Results In 40 eyes with treatment-naAaAaAeA ve DME (mean age, 55.8 years) visual acui (VA) (mean 59.6 EDTRS letters) was correlated with central macular thickness (CMT) (mean 536.9 [mu]m, R = -0.418, P = .008) and macular volume (MV) (mean 11.9 mm.sup.3, R = -0.449, P = .004). The NPA and ISI among the different retinal zones were significantly different (NPA: P .05). Conclusion In eyes with DME, the ISI increases with increasing distance from the fovea. The severity of DME does not appear to correlate with global NPA and ISI. Author Affiliation: (a) Doheny Image Reading Center, Doheny Eye Institute, Los Angeles, California (b) Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California (c) Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Ophthalmology and Visual Sciences Key Laboratory, Capital Medical University, Beijing, China (d) Department of Ophthalmology, Beijing Friendship Hospital, Capital Medical University, Beijing, China (e) Department of Ophthalmology, Yeungnam University College of Medicine, Daegu, South Korea (f) Retina Consultants of Houston, Houston, Texas (g) Blanton Eye Institute, Houston Methodist Hospital & Weill Cornell Medical College, Houston, Texas (h) Optos PLC, Dunfermline, United Kingdom * Inquiries to SriniVas R. Sadda, Doheny Eye Institute, PO Box 86228, Los Angeles, CA 90086 Article History: Accepted 25 May 2017 (footnote) Supplemental Material available at AJO.com(http://AJO.com). (footnote)* Drs Fan and Wang contributed equally to the work presented here.