학술논문
Pleiotropy of genetic variants on obesity and smoking phenotypes: Results from the Oncoarray Project of The International Lung Cancer Consortium
Document Type
Report
Author
Wang, Tao; Moon, Jee-Young; Wu, Yiqun; Amos, Christopher I.; Hung, Rayjean J.; Tardon, Adonina; Andrew, Angeline; Chen, Chu; Christiani, David C.; Albanes, Demetrios; Heijden, Erik H. F. M. van der; Duell, Eric; Rennert, Gadi; Goodman, Gary; Liu, Geoffrey; Mckay, James D.; Yuan, Jian-Min; Field, John K.; Manjer, Jonas; Grankvist, Kjell; Kiemeney, Lambertus A.; Marchand, Loic Le; Teare, M. Dawn; Schabath, Matthew B.; Johansson, Mattias; Aldrich, Melinda C.; Davies, Michael; Johansson, Mikael; Tsao, Ming-Sound; Caporaso, Neil; Lazarus, Philip; Lam, Stephen; Bojesen, Stig E.; Arnold, Susanne; Wu, Xifeng; Zong, Xuchen; Hong, Yun-Chul; Ho, Gloria Y. F.
Source
PLoS ONE. September 28, 2017, Vol. 12 Issue 9, e0185660
Subject
Language
English
ISSN
1932-6203
Abstract
Obesity and cigarette smoking are correlated through complex relationships. Common genetic causes may contribute to these correlations. In this study, we selected 241 loci potentially associated with body mass index (BMI) based on the Genetic Investigation of ANthropometric Traits (GIANT) consortium data and calculated a BMI genetic risk score (BMI-GRS) for 17,037 individuals of European descent from the Oncoarray Project of the International Lung Cancer Consortium (ILCCO). Smokers had a significantly higher BMI-GRS than never-smokers (p = 0.016 and 0.010 before and after adjustment for BMI, respectively). The BMI-GRS was also positively correlated with pack-years of smoking (p
Author(s): Tao Wang 1,*, Jee-Young Moon 1, Yiqun Wu 1,2, Christopher I. Amos 3, Rayjean J. Hung 4, Adonina Tardon 5, Angeline Andrew 6, Chu Chen 7, David C. Christiani [...]
Author(s): Tao Wang 1,*, Jee-Young Moon 1, Yiqun Wu 1,2, Christopher I. Amos 3, Rayjean J. Hung 4, Adonina Tardon 5, Angeline Andrew 6, Chu Chen 7, David C. Christiani [...]