학술논문
A comparative prospective study of the effects of ARV on liver enzymes in HIV positive patients with HCV co-infection and HCV naive patients attending ART Centre of JNIMS, Imphal
Original Research Article
hepatitis C virus coinfection in HIV patients on antiretrovirals in Imphal, India
Original Research Article
hepatitis C virus coinfection in HIV patients on antiretrovirals in Imphal, India
Document Type
Report
Source
Journal of Evolution of Medical and Dental Sciences. September 22, 2016, Vol. 5 Issue 76, p5606, 4 p.
Subject
Language
English
ISSN
2278-4748
Abstract
INTRODUCTION Manipur is a small Indian state in the eastern corner adjoining Myanmar and the first Human Immunodeficiency Virus (HIV) positive case was reported in February 1990 from the blood [...]
BACKGROUND An appreciably large fraction of the population of Manipur has been diagnosed as HIV/AIDS positive and an increase in the number of patients with HCV co-infection was observed, that led to dilemma of ART initiation at the background of liver problem. This study was taken up to solve such dilemma. MATERIALS AND METHODS A prospective followup of HIV positive cases attending ART Centre of JNIMS Hospital, Porompat, Imphal, Manipur was done among those who were screened for HCV infection and found positive and identical controls who were HCV negative for each HCV positive case from 1st January 2011 to 31st December 2015. During the period, all HCV co-infected cases who were started on ART were followed up every 3 months up to 6 months by selecting comparable HCV negative HIV patients who were similarly started on ART and monitored for changes in ALT level and CD4 count. RESULTS Improvement in ALT levels and CD4 counts were noted in both HCV co-infected and non-HCV co-infected HIV patient groups. CONCLUSION Initiation of ART had significantly better outcome in patients of HIV with low CD4 count whether they were associated with HCV co-infection or not. KEYWORDS HCV Co-infection, HIV, ALT Level, CD4 Count, JNIMS, Imphal, Manipur.
BACKGROUND An appreciably large fraction of the population of Manipur has been diagnosed as HIV/AIDS positive and an increase in the number of patients with HCV co-infection was observed, that led to dilemma of ART initiation at the background of liver problem. This study was taken up to solve such dilemma. MATERIALS AND METHODS A prospective followup of HIV positive cases attending ART Centre of JNIMS Hospital, Porompat, Imphal, Manipur was done among those who were screened for HCV infection and found positive and identical controls who were HCV negative for each HCV positive case from 1st January 2011 to 31st December 2015. During the period, all HCV co-infected cases who were started on ART were followed up every 3 months up to 6 months by selecting comparable HCV negative HIV patients who were similarly started on ART and monitored for changes in ALT level and CD4 count. RESULTS Improvement in ALT levels and CD4 counts were noted in both HCV co-infected and non-HCV co-infected HIV patient groups. CONCLUSION Initiation of ART had significantly better outcome in patients of HIV with low CD4 count whether they were associated with HCV co-infection or not. KEYWORDS HCV Co-infection, HIV, ALT Level, CD4 Count, JNIMS, Imphal, Manipur.