학술논문
Emerging roles of GluN3-containing NMDA receptors in the CNS
N-Methyl-D-aspartic acid receptors in the central nervous system
N-Methyl-D-aspartic acid receptors in the central nervous system
Document Type
Report
Source
Nature Reviews Neuroscience. October 2016, Vol. 17 Issue 10, p623, 13 p.
Subject
Language
English
ISSN
1471-003X
Abstract
Author(s): Isabel Pérez-Otaño (corresponding author) [1, 2]; Rylan S. Larsen [3]; John F. Wesseling [1] NMDA receptors (NMDARs) are glutamate-gated ion channels with central roles in synapse development and plasticity, [...]
GluN3-containing NMDA receptors (GluN3-NMDARs) are rarer than the 'classical' NMDARs, which are composed solely of GluN1 and GluN2 subunits, and have non-conventional biophysical, trafficking and signalling properties. In the CNS, they seem to have important roles in delaying synapse maturation until the arrival of sensory experience and in targeting non-used synapses for pruning. The reactivation of GluN3A expression at inappropriate ages may underlie maladaptive synaptic rearrangements observed in addiction, neurodegenerative diseases and other major brain disorders. Here, we discuss current evidence for these and other emerging roles for GluN3-NMDARs in the physiology and pathology of the CNS.
GluN3-containing NMDA receptors (GluN3-NMDARs) are rarer than the 'classical' NMDARs, which are composed solely of GluN1 and GluN2 subunits, and have non-conventional biophysical, trafficking and signalling properties. In the CNS, they seem to have important roles in delaying synapse maturation until the arrival of sensory experience and in targeting non-used synapses for pruning. The reactivation of GluN3A expression at inappropriate ages may underlie maladaptive synaptic rearrangements observed in addiction, neurodegenerative diseases and other major brain disorders. Here, we discuss current evidence for these and other emerging roles for GluN3-NMDARs in the physiology and pathology of the CNS.