학술논문
Associations between metals in residential environmental media and exposure biomarkers over time in infants living near a mining-impacted site
Original Article
Original Article
Document Type
Report
Author
Source
Journal of Exposure Science and Environmental Epidemiology. September 2016, Vol. 26 Issue 5, 510
Subject
Language
English
ISSN
1559-0631
Abstract
Author(s): Ami R Zota [1]; Anne M Riederer [1]; Adrienne S Ettinger [2]; Laurel A Schaider [3]; James P Shine [3]; Chitra J Amarasiriwardena [4]; Robert O Wright [3, 4]; [...]
Infant exposures to metals are a concern for mining-impacted communities, although limited information is available to assess residential exposures over the first year of life. We measured lead (Pb), manganese, arsenic, and cadmium in indoor air, house dust, yard soil, and tap water from 53 infants%apos; homes near the Tar Creek Superfund Site (Oklahoma, USA) at two time points representing developmental stages before and during initial ambulation (age 0-6 and 6-12 months). We measured infant metal biomarkers in: umbilical cord blood (n=53); 12- (n=43) and 24- (n=22) month blood; and hair at age 12 months (n=39). We evaluated cross-sectional and longitudinal associations between infant residential and biomarker concentrations. A doubling of mean dust Pb concentration was consistently associated with 36-49% higher 12-month blood Pb adjusting for cord blood Pb (P[precedes/equal to]0.05). Adjusted dust concentration explained 29-35% of blood Pb variance, and consistent associations with other media were not observed. Although concentrations in dust and blood were generally low, strong and consistent associations between dust and body burden suggest that house dust in mining-impacted communities may impact children%apos;s health. These relationships were observed at a young age, typically before blood Pb levels peak and when children%apos;s development may be particularly vulnerable to toxic insult. Journal of Exposure Science and Environmental Epidemiology (2016) 26, 510-519; doi: 10.1038/jes.2015.76; published online 9 December 2015 Keywords: children, exposure, home environment, infants, lead, metals, mining, Superfund
Infant exposures to metals are a concern for mining-impacted communities, although limited information is available to assess residential exposures over the first year of life. We measured lead (Pb), manganese, arsenic, and cadmium in indoor air, house dust, yard soil, and tap water from 53 infants%apos; homes near the Tar Creek Superfund Site (Oklahoma, USA) at two time points representing developmental stages before and during initial ambulation (age 0-6 and 6-12 months). We measured infant metal biomarkers in: umbilical cord blood (n=53); 12- (n=43) and 24- (n=22) month blood; and hair at age 12 months (n=39). We evaluated cross-sectional and longitudinal associations between infant residential and biomarker concentrations. A doubling of mean dust Pb concentration was consistently associated with 36-49% higher 12-month blood Pb adjusting for cord blood Pb (P[precedes/equal to]0.05). Adjusted dust concentration explained 29-35% of blood Pb variance, and consistent associations with other media were not observed. Although concentrations in dust and blood were generally low, strong and consistent associations between dust and body burden suggest that house dust in mining-impacted communities may impact children%apos;s health. These relationships were observed at a young age, typically before blood Pb levels peak and when children%apos;s development may be particularly vulnerable to toxic insult. Journal of Exposure Science and Environmental Epidemiology (2016) 26, 510-519; doi: 10.1038/jes.2015.76; published online 9 December 2015 Keywords: children, exposure, home environment, infants, lead, metals, mining, Superfund