학술논문
Physical Activity and Amyloid-[beta] Brain Levels in Elderly Adults with Intact Cognition and Mild Cognitive Impairment
Document Type
Report
Author
Souto Barreto, Philipe; Andrieu, Sandrine; Payoux, Pierre; Demougeot, Laurent; Rolland, Yves; Vellas, Bruno; Gillette-Guyonnet, Sophie; Carrie, Isabelle; Brigitte, Laureane; Faisant, Catherine; Lala, Francoise; Delrieu, Julien; Combrouze, Emeline; Badufle, Carole; Zueras, Audrey; Cantet, Christelle; Gardette, Virginie; Morin, Christophe; Kan, Gabor Abellan Van; Dupuy, Charlotte; Caillaud, Celine; Ousset, Pierre-Jean; Willis, Sherry; Belleville, Sylvie; Gilbert, Brigitte; Fontaine, Francine; Dartigues, Jean-Francois; Marcet, Isabelle; Delva, Fleur; Foubert, Alexandra; Cerda, Sandrine; Cuffi, Marie-Noelle; Costes, Corinne; Rouaud, Olivier; Manckoundia, Patrick; Quipourt, Valerie; Marilier, Sophie; Franon, Evelyne; Bories, Lawrence; Pader, Marie-Laure; Basset, Marie-France; Lapoujade, Bruno; Faure, Valerie; Tong, Michael Li Yung; Malick-Loiseau, Christine; Cazaban-Campistron, Evelyne; Desclaux, Francoise; Blatge, Colette; Dantoine, Thierry; Laubarie-Mouret, Cecile; Saulnier, Isabelle; Clement, Jean-Pierre; Picat, Marie-Agnes; Bernard-Bourzeix, Laurence; Willebois, Stephanie; Desormais, Ileana; Cardinaud, Noelle; Bonnefoy, Marc; Livet, Pierre; Rebaudet, Pascale; Gedeon, Claire; Burdet, Catherine; Terracol, Flavien; Pesce, Alain; Roth, Stephanie; Chaillou, Sylvie; Louchart, Sandrine; Sudres, Kristelle; Lebrun, Nicolas; Barro-Belaygues, Nadege; Touchon, Jacques; Bennys, Karim; Gabelle, Audrey; Romano, Aurelia; Touati, Lynda; Marelli, Cecilia; Pays, Cecile; Robert, Philippe; Duff, Franck Le; Gervais, Claire; Gonfrier, Sebastien; Gasnier, Yves; Bordes, Serge; Begorre, Daniele; Carpuat, Christian; Khales, Khaled; Lefebvre, Jean-Francois; Idrissi, Samira Misbah El; Skolil, Pierre; Salles, Jean-Pierre; Dufouil, Carole; Lehericy, Stephane; Chupin, Marie; Mangin, Jean-Francois; Bouhayia, Ali; Allard, Michele; Ricolfi, Frederic; Dubois, Dominique; Martel, Marie Paule Bonceour; Cotton, Francois; Bonafe, Alain; Chanalet, Stephane; Hugon, Francoise; Bonneville, Fabrice; Cognard, Christophe; Chollet, Francois; Voisin, Thierry; Peiffer, Sophie; Hitzel, Anne; Zanca, Michel; Monteil, Jacques; Darcourt, Jacques; Molinier, Laurent; Derumeaux, Helene; Costa, Nadege; Vincent, Christian; Perret, Bertrand; Vinel, Claire; Savy, S; Coley, N
Source
Journal of the American Geriatrics Society. August, 2015, Vol. 63 Issue 8, p1634, 6 p.
Subject
Language
English
ISSN
0002-8614
Abstract
Byline: Philipe Souto Barreto, Sandrine Andrieu, Pierre Payoux, Laurent Demougeot, Yves Rolland, Bruno Vellas, Sophie Gillette-Guyonnet, Isabelle Carrie, Laureane Brigitte, Catherine Faisant, Francoise Lala, Julien Delrieu, Emeline Combrouze, Carole Badufle, Audrey Zueras, Christelle Cantet, Virginie Gardette, Christophe Morin, Gabor Abellan Van Kan, Charlotte Dupuy, Celine Caillaud, Pierre-Jean Ousset, Sherry Willis, Sylvie Belleville, Brigitte Gilbert, Francine Fontaine, Jean-Francois Dartigues, Isabelle Marcet, Fleur Delva, Alexandra Foubert, Sandrine Cerda, Marie-Noelle Cuffi, Corinne Costes, Olivier Rouaud, Patrick Manckoundia, Valerie Quipourt, Sophie Marilier, Evelyne Franon, Lawrence Bories, Marie-Laure Pader, Marie-France Basset, Bruno Lapoujade, Valerie Faure, Michael Li Yung Tong, Christine Malick-Loiseau, Evelyne Cazaban-Campistron, Francoise Desclaux, Colette Blatge, Thierry Dantoine, Cecile Laubarie-Mouret, Isabelle Saulnier, Jean-Pierre Clement, Marie-Agnes Picat, Laurence Bernard-Bourzeix, Stephanie Willebois, Ileana Desormais, Noelle Cardinaud, Marc Bonnefoy, Pierre Livet, Pascale Rebaudet, Claire Gedeon, Catherine Burdet, Flavien Terracol, Alain Pesce, Stephanie Roth, Sylvie Chaillou, Sandrine Louchart, Kristelle Sudres, Nicolas Lebrun, Nadege Barro-Belaygues, Jacques Touchon, Karim Bennys, Audrey Gabelle, Aurelia Romano, Lynda Touati, Cecilia Marelli, Cecile Pays, Philippe Robert, Franck Le Duff, Claire Gervais, Sebastien Gonfrier, Yves Gasnier, Serge Bordes, Daniele Begorre, Christian Carpuat, Khaled Khales, Jean-Francois Lefebvre, Samira Misbah El Idrissi, Pierre Skolil, Jean-Pierre Salles, Carole Dufouil, Stephane Lehericy, Marie Chupin, Jean-Francois Mangin, Ali Bouhayia, Michele Allard, Frederic Ricolfi, Dominique Dubois, Marie Paule Bonceour Martel, Francois Cotton, Alain Bonafe, Stephane Chanalet, Francoise Hugon, Fabrice Bonneville, Christophe Cognard, Francois Chollet, Thierry Voisin, Sophie Peiffer, Anne Hitzel, Michel Zanca, Jacques Monteil, Jacques Darcourt, Laurent Molinier, Helene Derumeaux, Nadege Costa, Christian Vincent, Bertrand Perret, Claire Vinel, S Savy, N Coley Keywords: physical activity; amyloid plaques; Alzheimer's disease; older adults; elderly Objectives To examine the associations between amyloid-[beta] brain deposition and physical activity (PA) in elderly adults without dementia and to investigate whether the association has a dose-response relationship. Design Cross-sectional study. Setting French community-dwelling people. Participants Elderly adults with normal or mildly impaired cognition (mean age 74.7 [+ or -] 4.2; 60.4% female) with available information on current self-reported PA and amyloid-[beta] brain deposition measured using positron emission tomography (PET) using the PET-ligand florbetapir F 18 (n = 268). Measurements A standardized uptake value ratio (SUVR) was obtained for each subject. Participants were divided according to amyloid plaque cortical retention defined according to a SUVR cutoff of 1.10 (SUVR+ vs SUVR-). Results Bivariate and multivariate analyses showed that PA was not significantly associated with SUVR. SUVR+ and SUVR- participants did not differ in terms of volume (continuous PA variables) and levels (categorical PA variables) of PA. PA was not correlated with SUVR in apolipoprotein E I[micro]4 carriers or noncarriers. PA was not associated with cognitive function. Conclusion Although PA protects against dementia, there is no solid evidence that this protection involves a reduction in amyloid-[beta] brain deposition. Further studies are needed to determine whether PA (ideally measured at several time-points using objective measures) is involved in the pathophysiology of Alzheimer's disease. Article Note: See Appendix for the Multidomain Alzheimer Preventive Trial/Data Sharing Alzheimer Study Group. CAPTION(S): Data S1. PET-scan and physical activity measurements. Table S1. Types of physical activity (PA), metabolic equivalent (MET), classification in terms of physical activity (PA) domain, and prevalence of each activity in the study population (N = 268). Table S2. Multivariate binary logistic regression with confounders (N = 255). Table S3. Spearman rank correlations of physical activity (PA) variables with standardized uptake value ratio SUVR in the subgroup of participants not receiving multidomain Alzheimer preventive trial multidomain intervention (n = 128). Table S4. Spearman rank correlations of physical activity (PA) variables with cognitive function in the whole population (N = 268).