부산대학교 도서관

ABSTRACT Aims: This study, conducted in a 'field-practice' scenario, investigates the effectiveness and safety of everolimus in the second-line treatment of metastatic renal cell carcinoma (mRCC) patients. Patients & methods: mRCC patients, who started everolimus 10 mg/day after failure of first-line VEGF receptor-targeted tyrosine kinase inhibitor, were included in this study. Study end points were treatment response, progression-free survival and tolerability. Results: In total, 100 patients were assessed; the median duration of everolimus treatment was 7.1 months (95% CI: 5.7-8.5). A total of 19% of patients experienced a partial response and 62% of patients reached a stable disease. Median progression-free survival was 8 months (95% CI: 6.7-9.3). A total of 75% of patients experienced adverse events; no grade 4 adverse events were reported. Conclusion: These findings, obtained in a 'field-practice' scenario, support the use of everolimus for mRCC patients who failed one VEGF receptor-targeted tyrosine kinase inhibitor.
Author(s): Mimma Rizzo [sup.[*]] [sup.aff1] [sup.aff2] , Gaetano Facchini [sup.aff2] [sup.aff3] , Clementina Savastano [sup.aff2] [sup.aff3] , Giuseppe Di Lorenzo [sup.aff2] [sup.aff4] , Luigi De Lucia [sup.aff2] [sup.aff5] , Luigi [...]