학술논문
Predicting response to treatment for colorectal cancer: a review of relevant mechanisms and potential biomarkers
Document Type
Report
Author
Source
Colorectal Cancer. April 2015, Vol. 4 Issue 2, p85, 11 p.
Subject
Language
English
ISSN
1758-194X
Abstract
Author(s): Paul A Sutton [sup.[*]] [sup.aff1] [sup.aff2] , Rob P Jones [sup.aff1] [sup.aff3] , Jonathan P Evans [sup.aff1] , Neil Kitteringham [sup.aff1] , Chris Goldring [sup.aff1] , Dan H Palmer [...]
Neoadjuvant therapy for colorectal cancer offers potential oncological benefits but is associated with increased surgical risk. Predictive biomarkers would allow the personalization of this risk/benefit balance, with treatment stratified by likely response. Although current clinical application of predictive biomarkers is limited, a number of potential targets have been proposed. This review summarizes some of the approaches being used to develop predictive biomarkers for the personalization of colorectal cancer management.
Neoadjuvant therapy for colorectal cancer offers potential oncological benefits but is associated with increased surgical risk. Predictive biomarkers would allow the personalization of this risk/benefit balance, with treatment stratified by likely response. Although current clinical application of predictive biomarkers is limited, a number of potential targets have been proposed. This review summarizes some of the approaches being used to develop predictive biomarkers for the personalization of colorectal cancer management.