학술논문
Smac/DIABLO expression in human gastrointestinal carcinoma: association with clinicopathological parameters and survivin expression
Document Type
Report
Source
Oncology Letters. December 1, 2014, Vol. 8 Issue 6, p2581, 6 p.
Subject
Language
English
ISSN
1792-1074
Abstract
Lack of apoptosis is a key factor in carcinogenesis and tumor progression. Survivin is a member of the inhibitor of apoptosis protein (IAP) family. Second mitochondria-derived activator of caspases/direct inhibitor of apoptosis-binding protein with low pI (Smac/DIABLO) is an antagonist of IAPs. Recently, Smac/DIABLO was identified as a potent therapeutic target. However, the clinical significance of Smac/DIABLO in gastrointestinal carcinomas remains unclear. In the present study, Smac/DIABLO expression was analyzed by immunohistochemistry in 72 gastric adenocarcinomas and 78 colorectal adenocarcinomas. The expression of Smac/DIABLO was significantly higher in colorectal carcinoma than in gastric carcinoma. Additionally, a correlation was found between the expression of Smac/DIABLO and nuclear survivin in well- to moderately-differentiated colorectal adenocarcinomas (r=0.245; P Key words: survivin, Smac/DIABLO, immunohistochemistry, apoptosis
Introduction Second mitochondria-derived activator of caspases/direct inhibitor of apoptosis-binding protein with low pI (Smac/DIABLO) is a mitochondrial apoptogenic molecule that is released from the mitochondria in response to apoptotic stress. [...]
Introduction Second mitochondria-derived activator of caspases/direct inhibitor of apoptosis-binding protein with low pI (Smac/DIABLO) is a mitochondrial apoptogenic molecule that is released from the mitochondria in response to apoptotic stress. [...]