학술논문
Tracking the establishment of local endemic populations of an emergent enteric pathogen
Document Type
Report
Author abstract
Author abstract
Author
Holt, Kathryn E.; Nga, Tran Vu Thieu; Thanh, Duy Pham; Vinh, Ha; Kim, Dong Wook; Tra, My Phan Vu; Campbell, James I.; Van Minh Hoang, Nguyen; Vinh, Nguyen Thanh; Van Minh, Pham; Thuy, Cao Thu; Nga, Tran Thi Thu; Thompson, Corinne; Dung, Tran Thi Ngoc; Nhu, Nguyen Thi Khanh; Vinh, Phat Voong; Tuyet, Pham Thi Ngoc; Phuc, Hoang Le; Lien, Nguyen Thi Nam; Phu, Bui Duc; Ai, Nguyen Thi Thuy; Tien, Nguyen Manh; Dong, Nguyen; Parry, Christopher M.; Hien, Tran Tinh; Farrar, Jeremy J.; Parkhill, Julian; Dougan, Gordon; Thomson, Nicholas R.; Baker, Stephen
Source
Proceedings of the National Academy of Sciences of the United States. October 22, 2013, Vol. 110 Issue 43, p17522, 6 p.
Subject
Language
English
ISSN
0027-8424
Abstract
Shigella sonnei is a human-adapted pathogen that is emerging globally as the dominant agent of bacterial dysentery. To investigate local establishment, we sequenced the genomes of 263 Vietnamese S. sonnei isolated over 15 y. Our data show that S. sonnei was introduced into Vietnam in the 1980s and has undergone localized clonal expansion, punctuated by genomic fixation events through periodic selective sweeps. We uncover geographical spread, spatially restricted frontier populations, and convergent evolution through local gene pool sampling. This work provides a unique, high-resolution insight into the microevolution of a pioneering human pathogen during its establishment in a new host population. enteric disease | drug resistance | phylogeography | genomics www.pnas.org/cgi/doi/10.1073/pnas.1308632110