부산대학교 도서관

Purpose: To describe a combination of treatment modalities used for the successful eradication of Fusarium endophthalmitis. Design: Interventional case series. Participants: Three consecutive patients with keratitis-associated Fusarium endophthalmitis. Methods: After failure of traditional management options, a combination of intravitreal and long-term, high-dose systemic voriconazole, topical antifungal medications, and surgical intervention, with penetrating keratoplasty, lensectomy, and endoscopic-guided pars plana vitrectomy, was administered to each patient. Results: All three cases achieved full resolution of the infection, with a final Snellen visual acuity score of 20/50 to 20/70. Conclusions: An aggressive combination of therapeutic modalities, including the removal of subiris abscesses, might be needed for the successful resolution of Fusarium endophthalmitis. Keywords: endophthalmitis, fungal, Fusarium, keratitis, keratoplasty, voriconazole
Introduction Fusarium is a saprotrophic mold, with worldwide distribution, that is responsible for destructive mycotic keratitis. In portions of the Southern United States, keratomycosis accounts for 6% of all microbial [...]