학술논문
Induction of colonic regulatory T cells by indigenous Clostridium species
REPORTS
REPORTS
Document Type
Author abstract
Clinical report
Clinical report
Author
Source
Science. Jan 21, 2011, Vol. 331 Issue 6015, p337, 5 p.
Subject
Language
English
ISSN
0036-8075
Abstract
[CD4.sup.+] T regulatory cells ([T.sub.regs]), which express the Foxp3 transcription factor, play a critical role in the maintenance of immune homeostasis. Here, we show that in mice, [T.sub.regs] were most abundant in the colonic mucosa. The spore-forming component of indigenous intestinal microbiota, particularly dusters IV and XIVa of the genus Clostridium, promoted [T.sub.reg] cell accumulation. Colonization of mice by a defined mix of Clostridium strains provided an environment rich in transforming growth factor-[beta] and affected [Foxp3.sup.+] [T.sub.reg] number and function in the colon. Oral inoculation of Clostridium during the early Life of conventionally reared mice resulted in resistance to colitis and systemic immunogiobulin E responses in adult mice, suggesting a new therapeutic approach to autoimmunity and allergy. 10.1126/science.1198469