부산대학교 도서관

To authenticate to the full-text of this article, please visit this link: http://dx.doi.org/10.1111/j.1471-0528.2009.02357.x Byline: V Black (a), CE von Mollendorf (a), JA Moyes (a), LE Scott (b,c), A Puren (d), WS Stevens (b,c) Keywords: HIV; PMTCT; Rapid HIV test Abstract: We validated rapid HIV tests among pregnant women in a clinical setting. Field testing was performed using First Response 1,2,3 or Standard Diagnostic and Pareekshak tests. Results were confirmed by third generation HIV ELISA. Discordant or negative, specimens were confirmed by RNA PCR and a fourth generation ELISA test. Sensitivity and specificity were 94.5% (CI: 85.8-98.2) and 100% for First Response; 87.5% (CI: 46.7-99.3) and 100% (CI: 87.7-100%) for Standard Diagnostic and 90.2% (CI: 81.2-95.4) and 100% (CI: 98-100%) for Pareekshak. These sensitivities were lower than laboratory validation which approached 100%. The low-field sensitivity results have implications for Prevention of Mother-to-Child Transmission services. Author Affiliation: (a)Reproductive Health and HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa (b)Department of Molecular Medicine and Haematology, Faculty of Health Science, School of Pathology, University of the Witwatersrand and (c)National Health Laboratory Services, Johannesburg, South Africa University of Witwatersrand Medical School, Johannesburg, South Africa (d)Specialized Molecular Diagnostics Unit, National Institute for Communicable Diseases, Johannesburg, South Africa Article History: Accepted 24 July 2009. Published Online 14 September 2009. Article note: Dr V Black, Hugh Solomon Building, Corner Esselen and Klein Streets, Hilbrow 2001, South Africa. Email vblack@rhru.co.za